Abstract
Most people infected with human immunodeficiency virus 2 (HIV-2) do not progress to disease, even though the minority who do cannot be distinguished clinically from HIV-1-infected patients. Here we review what is known about the basis of viral control in HIV-2 infection.
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References
Gao, F. et al. Nature 397, 436–441 (1999).
Brenchley, J.M. et al. J. Exp. Med. 200, 749–759 (2004).
Brenchley, J.M. et al. Nat. Med. 12, 1365–1371 (2006).
Clavel, F. et al. Science 233, 343–346 (1986).
Martinez-Steele, E. et al. AIDS 21, 317–324 (2007).
Poulsen, A.G. et al. Lancet 349, 911–914 (1997).
Darby, S.C. et al. Nature 377, 79–82 (1995).
Popper, S.J. et al. J. Virol. 74, 1554–1557 (2000).
Berry, N. et al. AIDS Res. Hum. Retroviruses 18, 1167–1173 (2002).
Grassly, N.C. et al. J. Virol. 72, 7895–7899 (1998).
Ota, M.O. et al. AIDS 14, 435–439 (2000).
Ribeiro, A.C. et al. J. Virol. 79, 823–833 (2005).
Ylinen, L.M., Keckesova, Z., Wilson, S.J., Ranasinghe, S. & Towers, G.J. J. Virol. 79, 11580–11587 (2005).
Rowland-Jones, S.L. et al. Nat. Med. 1, 59–64 (1995).
Jaye, A. et al. J. Infect. Dis. 189, 498–505 (2004).
Zheng, N.N. et al. J. Virol. 78, 13934–13942 (2004).
Lopes, A.R. et al. J. Immunol. 171, 307–316 (2003).
Gillespie, G.M. et al. Eur. J. Immunol. 35, 1445–1453 (2005).
Duvall, M.G. et al. J. Immunol. 176, 6973–6981 (2006).
Douek, D.C. et al. Nature 417, 95–98 (2002).
Nuvor, S.V., van der Sande, M., Rowland-Jones, S., Whittle, H. & Jaye, A. J. Virol. 80, 2529–2538 (2006).
Weiss, R.A. et al. AIDS 2, 95–100 (1988).
Travers, K. et al. Science 268, 1612–1615 (1995).
Schim van der Loeff, M.F. et al. AIDS 15, 2303–10 (2001).
Silvestri, G. et al. Immunity 18, 441–452 (2003).
Jaffar, S. et al. AIDS Res. Hum. Retroviruses 21, 560–564 (2005).
Sousa, A.E., Carneiro, J., Meier-Schellersheim, M., Grossman, Z. & Victorino, R.M. J. Immunol. 169, 3400–3406 (2002).
Schindler, M. et al. Cell 125, 1055–1067 (2006).
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Rowland-Jones, S., Whittle, H. Out of Africa: what can we learn from HIV-2 about protective immunity to HIV-1?. Nat Immunol 8, 329–331 (2007). https://doi.org/10.1038/ni0407-329
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DOI: https://doi.org/10.1038/ni0407-329
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