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Systemic lupus erythematosus: an autoimmune disease of B cell hyperactivity

B cells can regulate many aspects of immune reactivity, as well as differentiate into antibody-producing cells. In SLE, a systemic autoimmune disease, recent research suggests enhanced B cell function is the defining pathogenic event.

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Figure 1: B cell regulation of normal immune responses and potential derangements in SLE.

Bob Crimi

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Lipsky, P. Systemic lupus erythematosus: an autoimmune disease of B cell hyperactivity. Nat Immunol 2, 764–766 (2001). https://doi.org/10.1038/ni0901-764

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