Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

All in the family: IL-27 suppression of TH-17 cells

Nature Immunology volume 7, pages 899–901 (2006)Cite this article

Interleukin 17 (IL-17)–producing T cells are associated with inflammatory conditions. Two studies now show that IL-27, an IL-12 family member with both pro- and anti-inflammatory properties, potently suppresses the development of IL-17-producing T cells.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Regulation of CD4+ T cell differentiation by IL-27.

Kim Caesar

References

  1. Watford, W.T., Moriguchi, M., Morinobu, A. & O'Shea, J.J. Cytokine Growth Factor Rev. 14, 361–368 (2003).

    Article  CAS  Google Scholar 

  2. Harrington, L.E., Mangan, P.R. & Weaver, C.T. Curr. Opin. Immunol. 18, 349–356 (2006).

    Article  CAS  Google Scholar 

  3. Hunter, C.A. Nat. Rev. Immunol. 5, 521–531 (2005).

    Article  CAS  Google Scholar 

  4. Batten, M. et al. Nat. Immunol. 7, 929–936 (2006).

    Article  CAS  Google Scholar 

  5. Stumhofer, J.S. et al. Nat. Immunol. 7, 937–945 (2006).

    Article  CAS  Google Scholar 

  6. Kishimoto, T. Annu. Rev. Immunol. 23, 1–21 (2005).

    Article  CAS  Google Scholar 

  7. Oppmann, B. et al. Immunity 13, 715–725 (2000).

    Article  CAS  Google Scholar 

  8. Pflanz, S. et al. Immunity 16, 779–790 (2002).

    Article  CAS  Google Scholar 

  9. Weaver, C.T. et al. Immunity 24, 677–688 (2006).

    Article  CAS  Google Scholar 

  10. Kolls, J.K. & Linden, A. Immunity 21, 467–476 (2004).

    Article  CAS  Google Scholar 

  11. Langrish, C.L. et al. J. Exp. Med. 201, 233–240 (2005).

    Article  CAS  Google Scholar 

  12. Mangan, P.R. et al. Nature 441, 231–234 (2006).

    Article  CAS  Google Scholar 

  13. Veldhoen, M. et al. Immunity 24, 179–189 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Internal Medicine, University of Iowa, Iowa City, 52242, Iowa, USA

    John Colgan & Paul Rothman

Authors
  1. John Colgan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Paul Rothman
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Colgan, J., Rothman, P. All in the family: IL-27 suppression of TH-17 cells. Nat Immunol 7, 899–901 (2006). https://doi.org/10.1038/ni0906-899

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni0906-899

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing