Studies of genetically modified reporter mice have provided insight into the development of regulatory T cells. New work shows that regulatory T cells producing interleukin 10 arise in the periphery from Foxp3+ and Foxp3− thymic progenitors.
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IL-10 transcription is negatively regulated by BAF180, a component of the SWI/SNF chromatin remodeling enzyme
BMC Immunology Open Access 15 February 2012
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Vieira, P., O'Garra, A. Regula'ten' the gut. Nat Immunol 8, 905–907 (2007). https://doi.org/10.1038/ni0907-905
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DOI: https://doi.org/10.1038/ni0907-905
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