While promiscuous expression of tissue-specific antigens (TSAs) in the thymus is essential for self-tolerance, immunologically relevant TSA expression may also occur in the secondary lymphoid organs. A new study links the transcriptional regulator Deaf1 with altered TSA expression in the secondary lymphoid organs and autoimmune diabetes.
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References
Yip, L. et al. Nat. Immunol. 10, 1026–1033 (2009).
Jolicoeur, C., Hanahan, D. & Smith, K.M. Proc. Natl. Acad. Sci. USA 91, 6707–6711 (1994).
Antonia, S.J., Geiger, T., Miller, J. & Flavell, R.A. Int. Immunol. 7, 715–725 (1995).
Derbinski, J., Schulte, A., Kyewski, B. & Klein, L. Nat. Immunol. 2, 1032–1039 (2001).
Nagamine, K. et al. Nat. Genet. 17, 393–398 (1997).
Anderson, M.S. et al. Science 298, 1395–1401 (2002).
Lee, J.W. et al. Nat. Immunol. 8, 181–190 (2007).
Nichols, L.A. et al. J. Immunol. 179, 993–1003 (2007).
Gardner, J.M. et al. Science 321, 843–847 (2008).
Kodama, K. et al. Clin. Immunol. 129, 195–201 (2008).
Gross, C.T. & McGinnis, W. EMBO J. 15, 1961–1970 (1996).
Veraksa, A., Kennison, J. & McGinnis, W. Genesis 33, 67–76 (2002).
Sugihara, T.M., Bach, I., Kioussi, C., Rosenfeld, M.G. & Andersen, B. Proc. Natl. Acad. Sci. USA 95, 15418–15423 (1998).
Hahm, K. et al. Mol. Cell. Biol. 24, 2074–2082 (2004).
Barker, H.E. et al. BMC Dev. Biol. 8, 94 (2008).
Huggenvik, J.I. et al. Mol. Endocrinol. 12, 1619–1639 (1998).
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Gardner, J., Anderson, M. The sickness unto Deaf. Nat Immunol 10, 934–936 (2009). https://doi.org/10.1038/ni0909-934
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DOI: https://doi.org/10.1038/ni0909-934