Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

The sickness unto Deaf

While promiscuous expression of tissue-specific antigens (TSAs) in the thymus is essential for self-tolerance, immunologically relevant TSA expression may also occur in the secondary lymphoid organs. A new study links the transcriptional regulator Deaf1 with altered TSA expression in the secondary lymphoid organs and autoimmune diabetes.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Putative TSA-expressing stromal populations in the lymph node.

References

  1. Yip, L. et al. Nat. Immunol. 10, 1026–1033 (2009).

    Article  CAS  Google Scholar 

  2. Jolicoeur, C., Hanahan, D. & Smith, K.M. Proc. Natl. Acad. Sci. USA 91, 6707–6711 (1994).

    Article  CAS  Google Scholar 

  3. Antonia, S.J., Geiger, T., Miller, J. & Flavell, R.A. Int. Immunol. 7, 715–725 (1995).

    Article  CAS  Google Scholar 

  4. Derbinski, J., Schulte, A., Kyewski, B. & Klein, L. Nat. Immunol. 2, 1032–1039 (2001).

    Article  CAS  Google Scholar 

  5. Nagamine, K. et al. Nat. Genet. 17, 393–398 (1997).

    Article  CAS  Google Scholar 

  6. Anderson, M.S. et al. Science 298, 1395–1401 (2002).

    Article  CAS  Google Scholar 

  7. Lee, J.W. et al. Nat. Immunol. 8, 181–190 (2007).

    Article  CAS  Google Scholar 

  8. Nichols, L.A. et al. J. Immunol. 179, 993–1003 (2007).

    Article  CAS  Google Scholar 

  9. Gardner, J.M. et al. Science 321, 843–847 (2008).

    Article  CAS  Google Scholar 

  10. Kodama, K. et al. Clin. Immunol. 129, 195–201 (2008).

    Article  CAS  Google Scholar 

  11. Gross, C.T. & McGinnis, W. EMBO J. 15, 1961–1970 (1996).

    Article  CAS  Google Scholar 

  12. Veraksa, A., Kennison, J. & McGinnis, W. Genesis 33, 67–76 (2002).

    Article  CAS  Google Scholar 

  13. Sugihara, T.M., Bach, I., Kioussi, C., Rosenfeld, M.G. & Andersen, B. Proc. Natl. Acad. Sci. USA 95, 15418–15423 (1998).

    Article  CAS  Google Scholar 

  14. Hahm, K. et al. Mol. Cell. Biol. 24, 2074–2082 (2004).

    Article  CAS  Google Scholar 

  15. Barker, H.E. et al. BMC Dev. Biol. 8, 94 (2008).

    Article  Google Scholar 

  16. Huggenvik, J.I. et al. Mol. Endocrinol. 12, 1619–1639 (1998).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Mark S Anderson.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gardner, J., Anderson, M. The sickness unto Deaf. Nat Immunol 10, 934–936 (2009). https://doi.org/10.1038/ni0909-934

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni0909-934

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing