Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Commentary
  • Published:

The Immunological Genome Project: networks of gene expression in immune cells

Abstract

The Immunological Genome Project combines immunology and computational biology laboratories in an effort to establish a complete 'road map' of gene-expression and regulatory networks in all immune cells

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: ImmGen consortium organization and project workflow.
Figure 2: Heat-map representation of 'problem transcripts' from replicate spleen CD4+ T cell samples (1 or 2) purified by each laboratory of the consortium (A–F) during the validation phase of the ImmGen profiling project.

References

  1. Hyatt, G. et al. Nat. Immunol. 7, 686–691 (2006).

    Article  CAS  PubMed  Google Scholar 

  2. Hoffmann, R., Bruno, L., Seidl, T., Rolink, A. & Melchers, F. J. Immunol. 170, 1339–1353 (2003).

    Article  CAS  PubMed  Google Scholar 

  3. Mick, V.E., Starr, T.K., McCaughtry, T.M., McNeil, L.K. & Hogquist, K.A. J. Immunol. 173, 5434–5444 (2004).

    Article  CAS  PubMed  Google Scholar 

  4. Edwards, A.D. et al. J. Immunol. 171, 47–60 (2003).

    Article  CAS  PubMed  Google Scholar 

  5. Fontenot, J.D. et al. Immunity 22, 329–341 (2005).

    Article  CAS  PubMed  Google Scholar 

  6. Kaech, S.M., Hemby, S., Kersh, E. & Ahmed, R. Cell 111, 837–851 (2002).

    Article  CAS  PubMed  Google Scholar 

  7. Matos, M., Park, R., Mathis, D. & Benoist, C. Diabetes 53, 2310–2321 (2004).

    Article  CAS  PubMed  Google Scholar 

  8. Bennett, L. et al. J. Exp. Med. 197, 711–723 (2003).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Ebert, B.L. & Golub, T.R. Blood 104, 923–932 (2004).

    Article  CAS  PubMed  Google Scholar 

  10. Shi, L. et al. Nat. Biotechnol. 24, 1151–1161 (2006).

    Article  CAS  PubMed  Google Scholar 

  11. Bammler, T. et al. Nat. Methods 2, 351–356 (2005).

    Article  PubMed  Google Scholar 

  12. Su, A.I. et al. Proc. Natl. Acad. Sci. USA 101, 6062–6067 (2004).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Abbas, A.R. et al. Genes Immun. 6, 319–331 (2005).

    Article  CAS  PubMed  Google Scholar 

  14. Splendiani, A. et al. BMC Bioinformatics 8 31, S21 (2007).

    Article  Google Scholar 

  15. Hijikata, A. et al. Bioinformatics 23, 2934–2941 (2007).

    Article  CAS  PubMed  Google Scholar 

  16. di Bernardo, D. et al. Nat. Biotechnol. 23, 377–383 (2005).

    Article  CAS  PubMed  Google Scholar 

  17. Segal, E. et al. Nat. Genet. 34, 166–176 (2003).

    Article  CAS  PubMed  Google Scholar 

  18. Lodish, H.F., Zhou, B., Liu, G. & Chen, C.Z. Nat. Rev. Immunol. 8, 120–130 (2008).

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

We thank eBiosciences, Affymetrix and Expression Analysis for participation and support. Supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (R24 AI072073 to C.B.).

Author information

Authors and Affiliations

Authors

Consortia

Rights and permissions

Reprints and permissions

About this article

Cite this article

Heng, T., Painter, M., The Immunological Genome Project Consortium. et al. The Immunological Genome Project: networks of gene expression in immune cells. Nat Immunol 9, 1091–1094 (2008). https://doi.org/10.1038/ni1008-1091

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni1008-1091

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing