The cancer stem cell (CSC) concept has provocative implications for our understanding of cancer biology and therapy. Its clinical relevance now receives a major boost from the finding that a stem cell–like or self-renewing gene expression signature can predict clinical outcome in acute myeloid leukemia (pages 1086–1093).
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Dick, J.E. Blood 112, 4793 (2008).
Shackleton, M., Quintana, E., Fearon, E.R. & Morrison, S.J. Cell 138, 822 (2009).
Rosen, J.M. & Jordan, C.T. Science 324, 1670–1673 (2009).
Anderson, K. et al. Nature 469, 356 (2011).
Scheel, C. et al. Cell 145, 926 (2011).
O'Brien, C.A., Kreso, A. & Jamieson, C.H.M. Clin. Cancer Res. 16, 3113 (2010).
Eppert, K. et al. Nat. Med. 17, 1086–1093 (2011).
Forsberg, E.C. et al. PLoS ONE 5, e8785 (2010).
Cicalese, A. et al. Cell 138, 1083–1095 (2009).
Gentles, A.J., Plevritis, S.K., Majeti, R. & Alizadeh, A.A. J. Am. Med. Assoc. 304, 2706 (2010).
Barjesteh van Waalwijk van Doorn-Khosrovani, S. et al. Blood 101, 837–845 (2003).
Meyer, L.H. et al. Cancer Cell 19, 206 (2011).
Merlos-Suárez, A. et al. Cell Stem Cell 8, 511–524 (2011).
Shats, I. et al. Cancer Res. 71, 1772 (2011).
Somervaille, T.C.P. et al. Cell Stem Cell 4, 129 (2009).
Ben-Porath, I. et al. Nat. Genet. 40, 499 (2008).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Greaves, M. Cancer stem cells renew their impact. Nat Med 17, 1046–1048 (2011). https://doi.org/10.1038/nm.2458
Published:
Issue Date:
DOI: https://doi.org/10.1038/nm.2458
This article is cited by
-
Overcoming Wnt–β-catenin dependent anticancer therapy resistance in leukaemia stem cells
Nature Cell Biology (2020)
-
ent-Atisane diterpenoids from Euphorbia fischeriana inhibit mammosphere formation in MCF-7 cells
Journal of Natural Medicines (2016)
-
Euphorins A–H: bioactive diterpenoids from Euphorbia fischeriana
Journal of Natural Medicines (2016)