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Activated basophils give lupus a booster shot

Basophils have recently been identified as antigen-presenting cells that are required for optimal antibody responses. New findings now show that activation of these cells can amplify autoimmune responses in systemic lupus erythematosus (SLE) (pages 701–707).

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Figure 1: Basophil activation by autoreactive IgE.

Kimberly Caesar

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Correspondence to Anne Davidson.

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Davidson, A., Diamond, B. Activated basophils give lupus a booster shot. Nat Med 16, 635–636 (2010). https://doi.org/10.1038/nm0610-635

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