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Building up the blood-brain barrier

Astrocyte projections extend to the blood-brain barrier (BBB) and promote its maturation. These astrocytes are now shown to secrete a factor that appears to integrate signaling networks necessary for BBB development and maintenance (pages 900–906).

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Figure 1: SSeCKS regulates BBB maturation.

Kimberly Homer

References

  1. Lee, S.W. et al. SSeCKS regulates angiogenesis and tight junction formation in blood-brain barrier. Nat. Med. 9, 900–906 (2003).

    Article  CAS  PubMed Central  Google Scholar 

  2. Engelhardt, B. & Risau, W. Development of the blood-brain barrier. in New Concepts of a Blood-Brain Barrier (eds. Greenwood, J., Begley, D., Segal, M. & Lightman, S.) 11–31 (Plenum Press, New York, 1995).

    Chapter  Google Scholar 

  3. Wolburg, H. & Lippoldt, A. Tight junctions of the blood-brain barrier. Development, composition and regulation. Vasc. Pharmacol. 28, 323–337 (2002).

    Article  Google Scholar 

  4. Janzer, R.C. & Raff, M.C. Astrocytes induce blood brain barrier properties in endothelial cells. Nature 325, 253–257 (1987).

    Article  CAS  PubMed Central  Google Scholar 

  5. Abbott, N.J. Astrocyte-endothelial interactions and blood-brain barrier permeability. J. Anat. 200, 629–638 (2002).

    Article  CAS  PubMed Central  Google Scholar 

  6. Song, H.S. et al. Oxygen tension regulates the maturation of the blood-brain barrier. Biochem. Biophys. Res. Commun. 290, 325–331 (2002).

    Article  CAS  PubMed Central  Google Scholar 

  7. Gelman, I.H. The role of SSeCKS/gravin/AKAP12 scaffolding proteins in the spaciotemporal control of signaling pathways in oncogenesis and development. Front. Biosci. 7, 11782–11797 (2002).

    Google Scholar 

  8. Ruhrberg, C. et al. Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis. Genes Dev. 16, 2684–2698 (2002).

    Article  CAS  PubMed Central  Google Scholar 

  9. Suri, C. et al. Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell 87, 1171–1180 (1996).

    Article  CAS  Google Scholar 

  10. Coats, S.R., Pabon-Pena, L.M., Covington, J.W. & Vaughan, D.E. Ligand-specific control of src-suppressed C kinase substrate gene. Biochem. Biophys. Res. Commun. 297, 1112–1120 (2002).

    Article  CAS  PubMed Central  Google Scholar 

  11. Antonetti, D.A. et al. Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1. A potential mechanism for vascular permeability in diabetic retinopathy and tumors. J. Biol. Chem. 274, 23463–23467 (1999).

    Article  CAS  PubMed Central  Google Scholar 

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Rieckmann, P., Engelhardt, B. Building up the blood-brain barrier. Nat Med 9, 828–829 (2003). https://doi.org/10.1038/nm0703-828

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