Normal cells can respond to expression of activated oncogenes by initiating cellular senescence, a permanent state of proliferative arrest. But whether this process reflects a relevant anticancer mechanism has been debated. Several studies now show that oncogene-induced senescence can occur in vivo and provides a bona fide barrier to tumorigenesis.
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Narita, M., Lowe, S. Senescence comes of age. Nat Med 11, 920–922 (2005). https://doi.org/10.1038/nm0905-920
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DOI: https://doi.org/10.1038/nm0905-920
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