The cell-cycle inhibitor p27 is phosphorylated by the Akt kinase in breast cancer, according to three new studies. This phosphorylation keeps p27 in the cytoplasm and correlates with cancer aggressiveness (pages 1136–1144, 1145–1152 and 1153–1160.)
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Identification, characterization, and prognosis investigation of pivotal genes shared in different stages of breast cancer
Scientific Reports Open Access 25 May 2023
-
Assessment of virulence potential of uncharacterized Enterococcus faecalis strains using pan genomic approach – Identification of pathogen–specific and habitat-specific genes
Scientific Reports Open Access 07 December 2016
-
Intrinsically disordered proteins (IDPs) in trypanosomatids
BMC Genomics Open Access 13 December 2014
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Kimberly Homer
References
Slingerland, J. & Pagano, M. Regulation of the cdk inhibitor p27 and its deregulation in cancer. J. Cell. Physiol. 183, 10–17 (2000).
Lian, J. et al. Akt/PKB phosphorylates p27, impairs nuclear import of p27and opposes p27-mediated G1 arrest. Nature Med. 8, 1153–1160 (2002).
Shin, I. et al. Akt/PKB mediates cell cycle progression by phosphorylation of p27Kip1 on threonine157 and modulation of its cellular localization. Nature Med. 8, 1145–1152 (2002).
Viglietto, G. et al. Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27Kip1 by Akt/PKB-mediated phosphorylation in breast cancer. Nature Med. 8, 1136–1144 (2002).
Sherr, C.J. & Roberts, J.M. CDK inhibitors: Positive and negative regulators of G1-phase progression. Genes Dev 13, 1501–1512 (1999).
Massagué, J., Blain, S.W. & Lo, R.S. TGF-β signaling in growth control, cancer and heritable disorders. Cell 103, 295–309 (2000).
Coffer, P.J., Jin, J. & Woodgett, J.R. Protein kinase B (c-Akt): A multifunctional mediator of phosphatidylinositol 3-kinase activation. Biochem. J. 335, 1–12 (1998).
Testa, J.R. & Bellacosa, A. Akt plays a central role in tumorigenesis. Proc. Natl. Acad. Sci. USA 98, 10983–10985 (2001).
Zhou, B.P. et al. HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation. Nature Cell Biol. 3, 973–982 (2001).
Medema, R.H., Kops, G.J., Bos, J.L. & Burgering, B.M. AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27Kip1. Nature 404, 782–787 (2000).
Di Cristofano, A., De Acetis, M., Koff, A., Cordon-Cardó, C. & Pandolfi, P.P. Pten and p27Kip1 cooperate in prostate cancer tumor suppression in the mouse. Nature Genet. 27, 222–224 (2001)
Tsihlias, J., Kapusta, L. & Slingerland, J. The prognostic significance of altered cyclin-dependent kinase inhibitors in human cancer. Annu. Rev. Med. 50, 401–423 (1999).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Blain, S., Massagué, J. Breast cancer banishes p27 from nucleus. Nat Med 8, 1076–1078 (2002). https://doi.org/10.1038/nm1002-1076
Issue Date:
DOI: https://doi.org/10.1038/nm1002-1076
This article is cited by
-
FOXO transcription factors as mediators of stress adaptation
Nature Reviews Molecular Cell Biology (2024)
-
Identification, characterization, and prognosis investigation of pivotal genes shared in different stages of breast cancer
Scientific Reports (2023)
-
Assessment of virulence potential of uncharacterized Enterococcus faecalis strains using pan genomic approach – Identification of pathogen–specific and habitat-specific genes
Scientific Reports (2016)
-
Intrinsically disordered proteins (IDPs) in trypanosomatids
BMC Genomics (2014)
-
BRAF V600E associates with cytoplasmatic localization of p27kip1 and higher cytokeratin 19 expression in papillary thyroid carcinoma
Endocrine (2013)
