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Introducing new vaccines into developing countries: obstacles, opportunities and complexities

Infectious diseases are thought to account for nearly 25% of all deaths worldwide, and extract a disproportionate toll in developing countries1. Moreover, infectious diseases are now appreciated to be major causes of the poverty and economic underdevelopment that characterize the world's poorest countries2. Development and deployment of new vaccines to prevent infectious diseases in developing countries have therefore become high priorities in the global health agenda.

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Figure 1: Residual uncertainties requiring evidence.

References

  1. World Health Organization. The World Health Report (World Health Organization, Geneva, 2003).

  2. Sachs, J. Bull. World Health Organ. 80, 167–169 (2002).

    PubMed  PubMed Central  Google Scholar 

  3. National Institute of Allergy and Infectious Diseases, National Institutes of Health. The Jordan Report. 20th Anniversary: Accelerated Development of Vaccines. 261 (National Institutes of Health, Bethesda, Maryland, USA, 2002).

  4. Hardon, A. & Blume, S. Soc. Sci. Med. 60, 345–356 (2005).

    Article  PubMed  Google Scholar 

  5. Milstein, J. & Belgharbi, L. Bull. World Health Organ. 82, 128–133 (2004).

    Google Scholar 

  6. Mahoney, R. & Maynard, J. Vaccine 17, 646–652 (1999).

    Article  CAS  PubMed  Google Scholar 

  7. Batson, A., Glass, S. & Seiguer, E. in The Vaccine Book (eds. Bloom, B. & Lambert, P.-H.) 345–370 (Academic Press, London, 2003).

    Book  Google Scholar 

  8. Gotuzzo, E. et al. Infect. Immun. 61, 3994–3997 (1993).

    CAS  PubMed  PubMed Central  Google Scholar 

  9. John, T.J. & Jayabal, P. Am. J. Epidemiol. 96, 263–269 (1972).

    Article  CAS  PubMed  Google Scholar 

  10. Hanlon, P. et al. Lancet 329, 1342–1345 (1987).

    Article  Google Scholar 

  11. Webber, D. & Kremer, M. Bull. World Health Organ. 79, 735–741 (2001).

    CAS  PubMed  PubMed Central  Google Scholar 

  12. Widdus, R. Bull. World Health Organ. 79, 713–720 (2001).

    CAS  PubMed  PubMed Central  Google Scholar 

  13. Alonso, P. et al. Lancet 364, 1411–1420 (2004).

    Article  CAS  PubMed  Google Scholar 

  14. Martin, J.F. & Marshall, J. Vaccine 21, 587–592 (2003).

    Article  PubMed  Google Scholar 

  15. Esparza, J. & Osmanov, S. Curr. Mol. Med. 3, 183–193 (2003).

    Article  CAS  PubMed  Google Scholar 

  16. Glass, R.I., Bresee, J.S., Parashar, U.D., Jiang, B. & Gentsch, J. Lancet 363, 1547–1550 (2004).

    Article  PubMed  Google Scholar 

  17. Salisbury, D. Pediatr. Infect. Dis. J. 17, S93–S95 (1998).

    Article  CAS  PubMed  Google Scholar 

  18. Taira, A.V. Emerg. Infect. Dis. 10, 1915–1923 (2004).

    Article  PubMed  PubMed Central  Google Scholar 

  19. Clemens, J., Brenner, R., Rao, M., Tafari, N. & Lowe, C. JAMA 275, 390–397 (1996).

    Article  CAS  PubMed  Google Scholar 

  20. Clements, C.J., Abdool-Karim, Q., Chang, M.L., Nkowane, B. & Esparza, J. Vaccine 22, 2822–2826 (2004).

    Article  CAS  PubMed  Google Scholar 

  21. DeRoeck, D., Nyamete, A., Mahoney, R. & Clemens, J. Vaccine 22, 121–129 (2003).

    Article  PubMed  Google Scholar 

  22. Mahoney, R. J. Health Popul. Nutr. 22, 331–337 (2004).

    PubMed  Google Scholar 

  23. Clemens, J & Jodar, L. J. Health Popul. Nutr. 22, 223–231 (2004).

    PubMed  Google Scholar 

  24. Levine, O., Cherian, T., Shah, R. & Batson, A. J. Health Popul. Nutr. 22, 268–274 (2004).

    PubMed  Google Scholar 

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Correspondence to John Clemens.

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Clemens, J., Jodar, L. Introducing new vaccines into developing countries: obstacles, opportunities and complexities. Nat Med 11 (Suppl 4), S12–S15 (2005). https://doi.org/10.1038/nm1225

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