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Drug delivery

One nanoparticle, one kill

By wrapping a ligand-functionalized lipid membrane around a silica core, nanoparticles with a fluid surface are created. These combine unprecedented specificity in binding to cancer cells with the combinatorial delivery of drug cocktails.

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Figure 1: A schematic outlining multivalent targeting in nanoparticle drug delivery.
Figure 2: The design of lipid-bilayer-wrapped nanoporous silica, termed protocells.

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Correspondence to Darrell J. Irvine.

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Irvine, D. One nanoparticle, one kill. Nature Mater 10, 342–343 (2011). https://doi.org/10.1038/nmat3014

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