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Polymers for gene delivery

Charged for success

DNA-complexated cationic polymers with reduced charge density, high molecular weight and increased hydrophobicity show a lack of detectable cytotoxicity and efficiently deliver the apoptosis-inducing TRAIL gene to transplanted tumours in mice.

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Figure 1: Cytotoxicity and transfection efficiency of polymer–plasmid DNA (pDNA) polyplexes.

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Correspondence to Enrico Mastrobattista or Wim E. Hennink.

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Mastrobattista, E., Hennink, W. Charged for success. Nature Mater 11, 10–12 (2012). https://doi.org/10.1038/nmat3209

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