Abstract
Peptide nucleic acid (PNA) or RNA directed against the genomic DNA sequence around the transcription start site effectively knock down the expression of the targeted gene and make for an effective addition to the arsenal of gene silencing methods.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Janowski, B. et al. Inhibiting transcription of chromosomal DNA with antigene peptide nucleic acids. Nat. Chem. Biol. 1, 210–215 (2005).
Janowski, B. et al. Inhibiting gene expression at transcription start sites in chromosomal DNA with antigene RNAs. Nat. Chem. Biol. 1, 216–222 (2005).
Rights and permissions
About this article
Cite this article
Rusk, N. All silent on the transcription front. Nat Methods 2, 726–727 (2005). https://doi.org/10.1038/nmeth1005-726b
Issue Date:
DOI: https://doi.org/10.1038/nmeth1005-726b
