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Neurod1 is essential for the survival and maturation of adult-born neurons

Nature Neuroscience volume 12, pages 1090–1092 (2009)Cite this article

Abstract

The transcriptional program that controls adult neurogenesis is unknown. We generated mice with an inducible stem cell–specific deletion of Neurod1, resulting in substantially fewer newborn neurons in the hippocampus and olfactory bulb. Thus, Neurod1 is cell-intrinsically required for the survival and maturation of adult-born neurons.

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Figure 1: Critical role of Neurod1 in adult hippocampal neurogenesis.
Figure 2: Neurod1 is required for the survival and maturation of adult-born granule cell neurons.
Figure 3: Neurod1 is required for neuronal, but not astrocyte, differentiation in neurosphere cultures.

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Acknowledgements

We thank L. Zhang, J. Ma and Y. Jiang for technical assistance and S. Goetsch for artwork. We also thank J. Johnson, C.-L. Zhang and J. Schneider for helpful comments on the manuscript. This work was supported in part by the Epilepsy Foundation (Z.G.), a US National Institutes of Health training grant (K.U.), the Texas Advanced Research Program (grant numbers 3594-0029-2007 and 10019-0013-2006), the Ellison Medical Foundation (grant number AG-NS-0371-06) and the Welch Foundation (grant number I-1660, J.H.).

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Author notes

  1. Zhengliang Gao and Kerstin Ure: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Molecular Biology and Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, Texas

    Zhengliang Gao, Kerstin Ure & Jenny Hsieh

  2. Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas

    Jessica L Ables & Amelia J Eisch

  3. Department of Cellular and Molecular Medicine & Heart and Stroke Foundation, Centre for Stroke Recovery, University of Ottawa, Ontario, Canada

    Diane C Lagace

  4. Department of Neurogenetics, Max-Planck Institute of Experimental Medicine, Göttingen, Germany

    Klaus-Armin Nave & Sandra Goebbels

Authors
  1. Zhengliang Gao
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  2. Kerstin Ure
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  3. Jessica L Ables
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  4. Diane C Lagace
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  5. Klaus-Armin Nave
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  6. Sandra Goebbels
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  7. Amelia J Eisch
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  8. Jenny Hsieh
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Contributions

Z.G., K.U. and J.H. conducted the experiments, contributed to the data analyses and designed the study. J.L.A. contributed to the Neurod1 expression analysis, K.-A.N. and S.G. provided the Neurod1loxP/loxP mice, and A.J.E. and D.C.L. provided Nes-CreERT2 mice and contributed conceptually to the project. The manuscript was written by J.H. and commented on by all authors.

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Correspondence to Jenny Hsieh.

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Supplementary Figures 1–10 and Supplementary Methods (PDF 665 kb)

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Gao, Z., Ure, K., Ables, J. et al. Neurod1 is essential for the survival and maturation of adult-born neurons. Nat Neurosci 12, 1090–1092 (2009). https://doi.org/10.1038/nn.2385

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