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Neuronal death or dismemberment mediated by Sox14

Nature Neuroscience volume 12, pages 1479–1480 (2009)Cite this article

The pruning of unneeded axons and dendrites is crucial for circuitry maturation, but poorly understood on the molecular level. During Drosophila metamorphosis, the transcription factor Sox14 acts as a context-dependent mediator of death, axonal or dendritic pruning. Its transcriptional target Mical acts specifically in dendrite pruning.

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Figure 1: Sox14 and Mical function during developmental sensory dendrite pruning in Drosophila.

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Authors and Affiliations

  1. Howard Hughes Medical Institute and Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA

    Jeannette M Osterloh & Marc R Freeman

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  1. Jeannette M Osterloh
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  2. Marc R Freeman
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Correspondence to Marc R Freeman.

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Osterloh, J., Freeman, M. Neuronal death or dismemberment mediated by Sox14. Nat Neurosci 12, 1479–1480 (2009). https://doi.org/10.1038/nn1209-1479

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