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Spatial navigation impairment in mice lacking cerebellar LTD: a motor adaptation deficit?

Nature Neuroscience volume 8, pages 1292–1294 (2005)Cite this article

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Abstract

L7-PKCI transgenic mice, which lack parallel fiber–Purkinje cell long-term depression (LTD), were tested with two different mazes to dissociate the relative importance of declarative and procedural components of spatial navigation. We show that L7-PKCI mice are deficient in acquisition of an adapted goal-oriented behavior, part of the procedural component of the task. This supports the hypothesis that cerebellar LTD may subserve a general sensorimotor adaptation process shared by motor and spatial learning functions. *Note: In the version of this article initially published online, the third author’s name was incorrect. The correct name is Mohammed reza Hojjati. The error has been corrected in the HTML and print versions of the article.

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Figure 1: Comparison of two spatial navigation tasks.
Figure 2: Inactivation of LTD in L7-PKCI mice affected their performance in the Morris water maze task.
Figure 3: L7-PKCI mutants were not impaired in solving the allocentric version of the starmaze task.

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Change history

  • 05 September 2005

    Replaced R initial with "reza"

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Acknowledgements

The authors thank M. Rutteman, V. Gautheron and F. Maloumian for technical support. L.R.-R. is supported by the Action Concertée Initiative 'Neurosciences intégratives et computationnelles' (NIC 0083), the Institut Fédératif de Recherche 52 'Transduction du signal: molécules à action centrale et périphérique', and the 'Groupement d'Intérêt Scientifique Longévité' (grant L0201). A.B. is supported by the Laboratoire Européen des Neurosciences de l'Action (LENA). C.I.D.Z. is supported by Nederlandse Organisatie voor Wetenschappelijk Onderzoek, the European Economic Community and Neuro-Bsik.

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Author notes

  1. Angelo Arleo

    Present address: Neuroscience Group, Sony Computer Science Laboratory, 6 rue Amyot, 75005, Paris, France

Authors and Affiliations

  1. Laboratoire de Physiologie de la Perception et de l'Action, UMR CNRS 7152, 11 place Marcelin Berthelot, Collège de France, Paris, 75005, France

    Eric Burguière, Angelo Arleo, Alain Berthoz & Laure Rondi-Reig

  2. Department of Neuroscience, Erasmus MC, 3000 DR, Rotterdam, The Netherlands

    Mohammad reza Hojjati, Ype Elgersma & Chris I De Zeeuw

  3. Department of Physiology, Shahrekord University of Medical Sciences, Iran

    Mohammad reza Hojjati

Authors
  1. Eric Burguière
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  2. Angelo Arleo
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  3. Mohammad reza Hojjati
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  4. Ype Elgersma
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  5. Chris I De Zeeuw
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  6. Alain Berthoz
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  7. Laure Rondi-Reig
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Corresponding author

Correspondence to Laure Rondi-Reig.

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The authors declare no competing financial interests.

Supplementary information

Supplementary Fig. 1

Hippocampal functions are not impaired in L7-PKCI. (PDF 834 kb)

Supplementary Fig. 2

Three-dimensional diagrams of the mean time spent by control and mutant mice at each location of the maze at different training phases. (PDF 931 kb)

Supplementary Fig. 3

Three-dimensional diagrams showing the mean time spent by the two groups of animals at each location of the Starmaze at the beginning (day 1) and at the end (day 13) of training. (PDF 1653 kb)

Supplementary Fig. 4

Abstract model describing the error-based cerebellar learning hypothesis. (PDF 301 kb)

Supplementary Table 1

General appearance and motor abilities of mice. (PDF 239 kb)

Supplementary Methods (PDF 42 kb)

Supplementary Note (PDF 18 kb)

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Burguière, E., Arleo, A., Hojjati, M. et al. Spatial navigation impairment in mice lacking cerebellar LTD: a motor adaptation deficit?. Nat Neurosci 8, 1292–1294 (2005). https://doi.org/10.1038/nn1532

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