Abstract
Growing evidence from primate neurophysiology and modeling indicates that in reaction time tasks, a perceptual choice is made when the firing rate of a selective cortical neural population reaches a threshold. This raises two questions: what is the neural substrate of the threshold and how can it be adaptively tuned according to behavioral demands? Using a biophysically based network model of spiking neurons, we show that local dynamics in the superior colliculus gives rise to an all-or-none burst response that signals threshold crossing in upstream cortical neurons. Furthermore, the threshold level depends only weakly on the efficacy of the cortico-collicular pathway. In contrast, the threshold and the rate of reward harvest are sensitive to, and hence can be optimally tuned by, the strength of cortico-striatal synapses, which are known to be modifiable by dopamine-dependent plasticity. Our model provides a framework to describe the main computational steps in a reaction time task and suggests that separate brain pathways are critical to the detection and adjustment of a decision threshold.
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Acknowledgements
We thank S. Fusi for early work on the computer program used in this study, and D. Lee and P. Miller for helpful comments on the manuscript. This work was supported by the Swartz Foundation and the US National Institutes of Health (MH 062349).
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Supplementary information
Supplementary Fig. 1
The sensitivity of the decision threshold to the cortico-collicular (Cx-SC) efficacy in the absence of the basal ganglia. (PDF 12 kb)
Supplementary Fig. 2
Full network simulations in which single CD neurons are endowed with additional intrinsic ion channel mechanisms and exhibit Up and Down membrane states. (PDF 1078 kb)
Supplementary Fig. 3
Relationship between the bound height in the diffusion model and parameters of our model. (PDF 1065 kb)
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Lo, CC., Wang, XJ. Cortico–basal ganglia circuit mechanism for a decision threshold in reaction time tasks. Nat Neurosci 9, 956–963 (2006). https://doi.org/10.1038/nn1722
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DOI: https://doi.org/10.1038/nn1722
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