Abstract
Most cancer epidemiology studies involve people living in North America and Europe, which represent only a fraction of the global population. The wide variety of dietary, lifestyle and environmental exposures, as well as the genetic variation among people in developing countries can provide valuable new information on factors that contribute to cancer or that protect against it. What are the challenges and advantages to performing large epidemiological studies in developing nations?
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References
Parkin, D. M., Whelan, S. L., Ferlay, J., Teppo, L. & Thomas, B. D. Cancer Incidence in the Five Continents VIII. IARC Scientific Publication No. 155 (International Agency for Research on Cancer (IARC) Press, Lyon, France, 2002).
Dunn, J. E. Cancer epidemiology in populations of the United States — with emphasis on Hawaii and California — and Japan. Cancer Res. 35, 3240–3245 (1975).
Yu, H., Harris, R. E., Gao, Y. T., Gao, R. & Wynder, E. L. Comparative epidemiology of cancers of the colon, rectum, prostate and breast in Shanghai, China versus the United States. Int. J. Epidemiol. 20, 76–81 (1991).
Yiu, H. Y., Whittemore, A. S. & Shibata, A. Increasing colorectal cancer incidence rates in Japan. Int. J. Cancer 109, 777–781 (2004).
Hebert, J. R. et al. Sources of variability in dietary intake in two distinct regions of rural India: implications for nutrition study design and interpretation. Eur. J. Clin. Nutr. 54, 479–486 (2000).
Zain, R. B. Cultural and dietary risk factors of oral cancer and precancer — a brief overview. Oral Oncol. 37, 205–210 (2001).
Gupta, P. C., Sinor, P. N., Bhonsle, R. B., Pawar, V. S. & Mehta, H. C. Oral submucous fibrosis in India: a new epidemic? Natl Med. J. India 11, 113–116 (1998).
Sharma, D. C. Betel quid and areca nut are carcinogenic without tobacco. Lancet Oncol. 4, 587 (2003).
Lee, J. K., Park, B. J., Yoo, K. Y. & Ahn, Y. O. Dietary factors and stomach cancer: a case-control study in Korea. Int. J. Epidemiol. 24, 33–41 (1995).
Lopez-Carrillo, L., Hernandez Avila, M. & Dubrow, R. Chili pepper consumption and gastric cancer in Mexico: a case-control study. Am. J. Epidemiol. 139, 263–271 (1994).
Ji, B. T. et al. Dietary habits and stomach cancer in Shanghai, China. Int. J. Cancer 76, 659–664 (1998).
Ye, W. M. et al. Diet and gastric cancer: a casecontrol study in Fujian Province, China. World J. Gastroenterol. 4, 516–518 (1998).
Ngoan, L. T., Mizoue, T., Fujino, Y., Tokui, N. & Yoshimura, T. Dietary factors and stomach cancer mortality. Br. J. Cancer 87, 37–42 (2002).
Tsugane, S., Sasazuki, S., Kobayashi, M. & Sasaki, S. Salt and salted food intake and subsequent risk of gastric cancer among middle-aged Japanese men and women. Br. J. Cancer 90, 128–134 (2004).
World Cancer Research Fund. Food, Nutrition and the Prevention of Cancer: A Global Perspective (World Cancer Research Fund, American Institute for Cancer Research, Washington DC, 1997).
Pisani, P., Parkin, D. M., Munoz, N. & Ferlay, J. Cancer and infection: estimates of the attributable fraction in 1990. Cancer Epidemiol. Biomarkers Prev. 6, 387–400 (1997).
Franco, E. L., Schlecht, N. F. & Saslow, D. The epidemiology of cervical cancer. Cancer J. 9, 348–359 (2003).
Munoz, N. Human papillomavirus and cancer: the epidemiological evidence. J. Clin. Virol. 19, 1–5 (2000).
Clifford, G. M., Smith, J. S., Aguado, T. & Franceschi, S. Comparison of HPV type distribution in high-grade cervical lesions and cervical cancer: a meta-analysis. Br. J. Cancer 89, 101–105 (2003).
Huang, J. Q., Zheng, G. F., Sumanac, K., Irvine, E. J. & Hunt, R. H. Meta-analysis of the relationship between cagA seropositivity and gastric cancer. Gastroenterology 125, 1636–1644 (2003).
Montalto, G. et al. Epidemiology, risk factors, and natural history of hepatocellular carcinoma. Ann. NY Acad. Sci. 963, 13–20 (2002).
Yu, M. C., Yuan, J. M., Govindarajan, S. & Ross, R. K. Epidemiology of hepatocellular carcinoma. Can. J. Gastroenterol. 14, 703–709 (2000).
Ming, L. et al. Dominant role of hepatitis B virus and cofactor role of aflatoxin in hepatocarcinogenesis in Qidong, China. Hepatology 36, 1214–1220 (2002).
Turner, P. C. et al. The role of aflatoxins and hepatitis viruses in the etiopathogenesis of hepatocellular carcinoma: a basis for primary prevention in Guinea-Conakry, West Africa. J. Gastroenterol. Hepatol. 17, S441–S448 (2002).
Hall, A. J. & Wild, C. P. Liver cancer in low and middle income countries. BMJ 326, 994–995 (2003).
Koutsky, L. A. et al. A controlled trial of a human papillomavirus type 16 vaccine. N. Engl. J. Med. 347, 1645–1651 (2002).
Chang, M. H. et al. Hepatitis B vaccination and hepatocellular carcinoma rates in boys and girls. JAMA 284, 3040–3042 (2000).
Lubin, J. H. et al. Risk of lung cancer and residential radon in China: pooled results of two studies. Int. J. Cancer 109, 132–137 (2004).
Kleinerman, R. et al. Lung cancer and indoor air pollution in rural china. Ann. Epidemiol. 10, 469 (2000).
Bruce, N., Perez-Padilla, R. & Albalak, R. Indoor air pollution in developing countries: a major environmental and public health challenge. Bull. World Health Organ. 78, 1078–1092 (2000).
Zhou, B. S., Wang, T. J., Guan, P. & Wu, J. M. Indoor air pollution and pulmonary adenocarcinoma among females: a case-control study in Shenyang, China. Oncol. Rep. 7, 1253–1259 (2000).
Smith, K. R. Inaugural article: national burden of disease in India from indoor air pollution. Proc. Natl Acad. Sci. USA 97, 13286–13293 (2000).
Kleinerman, R. A. et al. Lung cancer and indoor exposure to coal and biomass in rural China. J. Occup. Environ. Med. 44, 338–344 (2002).
Lan, Q., Chapman, R. S., Schreinemachers, D. M., Tian, L. & He, X. Household stove improvement and risk of lung cancer in Xuanwei, China. J. Natl Cancer. Inst. 94, 826–835 (2002).
Chen, Y. & Ahsan, H. Cancer burden from arsenic in drinking water in Bangladesh. Am. J. Public Health 94, 741–744 (2004).
Khan, M. M., Sakauchi, F., Sonoda, T., Washio, M. & Mori, M. Magnitude of arsenic toxicity in tube-well drinking water in Bangladesh and its adverse effects on human health including cancer: evidence from a review of the literature. Asian Pac. J. Cancer Prev. 4, 7–14 (2003).
Lamm, S. H., Byrd, D. M., Kruse, M. B., Feinleib, M. & Lai, S. H. Bladder cancer and arsenic exposure: differences in the two populations enrolled in a study in southwest Taiwan. Biomed. Environ. Sci. 16, 355–368 (2003).
Guo, H. R. Arsenic level in drinking water and mortality of lung cancer (Taiwan). Cancer Causes Control 15, 171–177 (2004).
Xia, Y. & Liu, J. An overview on chronic arsenism via drinking water in PR China. Toxicology 198, 25–29 (2004).
Ferreccio, C. et al. Lung cancer and arsenic concentrations in drinking water in Chile. Epidemiology 11, 673–679 (2000).
Weinberg, C. Arsenic and drinking water. Epidemiology 15, 255–256 (2004).
Jha, P., Ranson, M. K., Nguyen, S. N. & Yach, D. Estimates of global and regional smoking prevalence in 1995, by age and sex. Am. J. Public Health 92, 1002–1006 (2002).
Chattopadhyay, B. P., Alam, J. & Roychowdhury, A. Pulmonary function abnormalities associated with exposure to automobile exhaust in a diesel bus garage and roads. Lung 181, 291–302 (2003).
Ueno, D. et al. Global pollution monitoring of PCBs and organochlorine pesticides using skipjack tuna as a bioindicator. Arch. Environ. Contam. Toxicol. 45, 378–389 (2003).
Zahm, S. H., Ward, M. H. & Blair, A. Pesticides and cancer. Occup. Med. 12, 269–289 (1997).
Dosemeci, M. et al. Cohort study among workers exposed to benzene in China: II. Exposure assessment. Am. J. Ind. Med. 26, 401–411 (1994).
Hallal, P. C., Victora, C. G., Wells, J. C. & Lima, R. C. Physical inactivity: prevalence and associated variables in Brazilian adults. Med. Sci. Sports Exerc. 35, 1894–1900 (2003).
Rastogi, T. et al. Physical activity and risk of coronary heart disease in India. Int. J. Epidemiol. (2004).
Tudor-Locke, C., Ainsworth, B. E., Adair, L. S., Du, S. & Popkin, B. M. Physical activity and inactivity in Chinese school-aged youth: the China Health and Nutrition Survey. Int. J. Obes. Relat. Metab. Disord. 27, 1093–1099 (2003).
Boyd, D. B. Insulin and cancer. Integr. Cancer Ther. 2, 315–329 (2003).
Calle, E. E. & Kaaks, R. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nature Rev. Cancer 4, 579–591 (2004).
Gajalakshmi, V., Peto, R., Kanaka, S. & Balasubramanian, S. Verbal autopsy of 48 000 adult deaths attributable to medical causes in Chennai (formerly Madras), India. BMC Public Health 2, 7 (2002).
Murray, C. J. L., Lopez, A. D. & World Health Organization. The Global Burden of Disease, Volume 1. A comprehensive assessment of mortality and disability from diseases, injuries, and risk factors in 1990 and projected to 2020 (Harvard University Press, Cambridge, Massachusetts, 1996).
Ferlay, J., Bray, F., Pisani, P. & Parkin, D. M. Cancer Incidence, Mortality and Prevalence Worldwide, Globocan, 2000 (International Agency for Research on Cancer (IARC) Press, World Health Organization, Lyon, France, 2001).
Sham, A. S., Cheung, L. K., Jin, L. J. & Corbet, E. F. The effects of tobacco use on oral health. Hong Kong Med. J. 9, 271–277 (2003).
Zain, R. B. et al. Oral mucosal lesions associated with betel quid, areca nut and tobacco chewing habits: consensus from a workshop held in Kuala Lumpur, Malaysia, November 25-27, 1996. J. Oral Pathol. Med. 28, 1–4 (1999).
Lee, S. A. et al. Effect of diet and Helicobacter pylori infection to the risk of early gastric cancer. J. Epidemiol. 13, 162–168 (2003).
Pandey, M., Mathew, A. & Nair, M. K. Global perspective of tobacco habits and lung cancer: a lesson for third world countries. Eur. J. Cancer Prev. 8, 271–279 (1999).
Zhong, L., Goldberg, M. S., Gao, Y. T. & Jin, F. A case-control study of lung cancer and environmental tobacco smoke among nonsmoking women living in Shanghai, China. Cancer Causes Control 10, 607–616 (1999).
Nagataki, S. & Nystrom, E. Epidemiology and primary prevention of thyroid cancer. Thyroid 12, 889–896 (2002).
Acknowledgements
We thank Mustafa Dosemeci for his input on the role of environmental risk factors in cancer aetiology.
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Rastogi, T., Hildesheim, A. & Sinha, R. Opportunities for cancer epidemiology in developing countries. Nat Rev Cancer 4, 909–917 (2004). https://doi.org/10.1038/nrc1475
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DOI: https://doi.org/10.1038/nrc1475
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