Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Fresh from the Pipeline
  • Published:

Oxaliplatin

Abstract

Oxaliplatin (Eloxatin; Sanofi-Synthelabo) is the first platinum-based anticancer drug to be approved for the treatment of colorectal cancer, a major cause of cancer deaths worldwide. Following European approval in 1999, has approval of oxaliplatin by the US FDA in August 2002 set it on the road to becoming a blockbuster?

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Platinum-based anticancer drugs.
Figure 2: Market for drugs to treat colorectal cancer in US $ million.

References

  1. Parkin, D. M. et al. Cancer burden in the year 2000. The global picture. Eur. J. Cancer 37, S4–S66 (2001).

    Article  Google Scholar 

  2. Longley, D. B. et al. 5-fluorouracil: mechanisms of action and clinical strategies. Nature Rev. Cancer 3, 330–338 (2003).

    Article  CAS  Google Scholar 

  3. Jamieson, E. R. & Lippard, S. J. Structure, recognition, and processing of cisplatin–DNA adducts. Chem. Rev. 99, 2467–2498 (1999).

    Article  CAS  Google Scholar 

  4. Di Francesco, A. M. et al. Cellular and molecular aspects of drugs of the future: oxaliplatin. Cell. Mol. Life Sci. 59, 1914–1927 (2002).

    Article  CAS  Google Scholar 

  5. Raymond, E. et al. Oxaliplatin: mechanism of action and antineoplastic activity. Semin. Oncol. 25, 4–12 (1998).

    CAS  PubMed  Google Scholar 

  6. Rixe, O. et al. Oxaliplatin, tetraplatin, cisplatin, and carboplatin: spectrum of activity in drug-resistant cell lines and in the cell lines of the National Cancer Institute's Anticancer Drug Screen Panel. Biochem. Pharmacol. 52, 1855–1865 (1996).

    Article  CAS  Google Scholar 

  7. FDA Drug Approvals List [online], (cited 28 November 2003), <http://www.fda.gov/cder/foi/label/2002/21492lbl.pdf> (2002).

  8. Goldberg, R. M. et al. A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer. J. Clin. Oncol. Dec 9 2003 (doi: 10.1200/JCO.2004.09.046)

  9. De Gramont, A. et al. Oxaliplatin/5-FU/LV in adjuvant colon cancer: results of the international randomized mosaic trial. Proc. Am. Soc. Clin. Oncol. 22, 253 (2003).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Joanne Graham.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Graham, J., Muhsin, M. & Kirkpatrick, P. Oxaliplatin. Nat Rev Drug Discov 3, 11–12 (2004). https://doi.org/10.1038/nrd1287

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrd1287

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing