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Jurkat T cells and development of the T-cell receptor signalling paradigm

Nature Reviews Immunology volume 4, pages 301–308 (2004)Cite this article

Abstract

Twenty years of investigation have yielded a detailed view of the signalling machinery engaged by T-cell receptors (TCRs). Many of the fundamental insights into TCR signalling came from studies carried out with transformed T-cell lines. Perhaps the best known of these model systems is the Jurkat leukaemic T-cell line, and here we review some of the key advances in the field of TCR signalling that were made with Jurkat T cells as the host.

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Figure 1: Generalized protocol for the selection and analysis of Jurkat-derived T-cell receptor (TCR)-signalling mutants.
Figure 2: Proximal signalling complexes and downstream responses induced by T-cell receptor (TCR) ligation.
Figure 3: Publications that list the term 'Jurkat' as a keyword, grouped according to publication year.

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Acknowledgements

We thank the reviewers for their helpful comments, and apologize to the many investigators whose valuable contributions have not been cited due to space constraints.

Author information

Authors and Affiliations

  1. the Program in Signal Transduction Research at The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, 92037, California, USA

    Robert T. Abraham

  2. the Departments of Medicine and of Microbiology and Immunology, Howard Hughes Medical Institute, Rosalind Russell Center for Medical Research in Arthritis, University of California, San Francisco, 94143-0795, USA

    Arthur Weiss

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  1. Robert T. Abraham
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Correspondence to Robert T. Abraham.

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Related links

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DATABASES

LocusLink

CARMA1

CD45

FYN

HM1

IKK-γ

IL-2

ITK

LAT

LCK

PLC-γ1

PTEN

RIP

SHIP

SLP76

SYK

TNF

VAV1

ZAP70

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Abraham, R., Weiss, A. Jurkat T cells and development of the T-cell receptor signalling paradigm. Nat Rev Immunol 4, 301–308 (2004). https://doi.org/10.1038/nri1330

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