Abstract
Iron–sulphur clusters are important cofactors for proteins that are involved in many cellular processes, including electron transport, enzymatic catalysis and regulation. The enzymes that catalyse the formation of iron–sulphur clusters are widely conserved from bacteria to humans. Recent studies in model systems and humans reveal that iron–sulphur proteins have important roles in mitochondrial iron homeostasis and in the pathogenesis of the human disease Friedreich ataxia.
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Acknowledgements
We thank A. Dancis, M. Pandolfo, H. Puccio and D. Dean for kindly sharing unpublished data.
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Rouault, T., Tong, WH. Iron–sulphur cluster biogenesis and mitochondrial iron homeostasis. Nat Rev Mol Cell Biol 6, 345–351 (2005). https://doi.org/10.1038/nrm1620
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DOI: https://doi.org/10.1038/nrm1620
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