Abstract
When Shigella infect the intestinal epithelium, they deliver several effectors through the type III secretion system (T3SS) into the surrounding space and directly into the host-cell cytoplasm, where they can mimic and usurp host cellular functions or subvert host-cell signalling pathways and the immune response. Although bacterial strategies and mechanisms of infection vary greatly, recent studies of Shigella effectors have revealed that Shigella possess a highly evolved strategy for infection.
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Acknowledgements
This work was supported by a Grant-in-aid for the Scientific Research on Priority Areas, Grant-in-aid-for Scientific Research (C) and Grant-in-aid-for Young Scientists (B) from the Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT) and the Special Coordination Funds for Promoting Science from Japan Science and Technology Agency (JSTA).
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Ogawa, M., Handa, Y., Ashida, H. et al. The versatility of Shigella effectors. Nat Rev Microbiol 6, 11–16 (2008). https://doi.org/10.1038/nrmicro1814
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DOI: https://doi.org/10.1038/nrmicro1814
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