Abstract
Glutamate is the principal excitatory neurotransmitter of the central nervous system, but many studies have expanded its functional repertoire by showing that glutamate receptors are present in a variety of non-excitable cells. How does glutamate receptor activation modulate their activity? Do non-excitable cells release glutamate, and, if so, how? These questions remain enigmatic. Here, we review the current knowledge on glutamatergic signalling in non-neuronal cells, with a special emphasis on astrocytes.
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Acknowledgements
This work was supported, in part, by NIEDH-NIH grants to M.N. We thank A. Cooper, G. M. Knudsen, G. Dienel and A. Schouboe for useful comments, X. Wang for the immunohistochemical analysis of glutamate receptor expression, and J. Rothstein for glutamate transporter antibodies.
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Nedergaard, M., Takano, T. & Hansen, A. Beyond the role of glutamate as a neurotransmitter. Nat Rev Neurosci 3, 748–755 (2002). https://doi.org/10.1038/nrn916
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DOI: https://doi.org/10.1038/nrn916