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Three-dimensional structure of staphylokinase, a plasminogen activator with therapeutic potential

The three-dimensional structure of staphylokinase has been determined at 1.8 Å.The puntative site of interaction with plasminogen was identified and epitopes were mapped.

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References

  1. Lack, C.H. Nature 161, 559–560 (1948).

    Article  CAS  Google Scholar 

  2. Collen, D. & Van de Werf, F. Circulation 87, 1850–1852 (1993).

    Article  CAS  Google Scholar 

  3. Vanderschueren, S. et al. Circulation 92, 2044–2049 (1995)

    Article  CAS  Google Scholar 

  4. Gase, A. et al. Eur. J. Biochem. 223, 303–308 (1994).

    Article  CAS  Google Scholar 

  5. Collen, D., De Mol, M., Demarsin, E., De Cock, F. & Stassen, J.M. Fibrinolysis 7, 242–247 (1993).

    Article  CAS  Google Scholar 

  6. Schlott, B. et al. BiolTechnology 12, 185–189 (1994)

    CAS  Google Scholar 

  7. Collen, D. et al. J. Biol. Chem. 268, 8284–8289 (1993)

    CAS  Google Scholar 

  8. Lijnen, H.R. et al. J. Biol. Chem. 266, 11826–11832 (1991)

    CAS  Google Scholar 

  9. Damaschun, G. et al. Biochim. Biophys. Acta 1161, 244–248 (1993).

    Article  CAS  Google Scholar 

  10. Silence, K., Collen, D. & Lijnen, H.R. Blood 3, 605–614 (1992).

    Google Scholar 

  11. Hauptmann, J. & Glusa, E. Blood Coag. Fibrinol. 6, 579–583 (1995).

    Article  CAS  Google Scholar 

  12. Collen, D., De Cock, F. & Stassen, J.M. Circulation 87, 996–1006 (1993).

    Article  CAS  Google Scholar 

  13. Stassen, J.M., Nyström, Å., Hoylaerts, M. & Collen, D. Circulation 91, 1330–1335 (1995).

    Article  CAS  Google Scholar 

  14. Vanderschueren, S., Stassen, J.M. & Collen, D. Thromb. Haemost. 72, 297–301 (1994).

    Article  CAS  Google Scholar 

  15. Boutonnet, N.S., Rooman, M.J., Ochagavia, M.E., Richelle, J. & Wodak, S.J. Prot Eng. 8, 647–662 (1995).

    Article  CAS  Google Scholar 

  16. Delhaise, P., Bardiaux, M. & Wodak, S. J. Mol. Graph. 2, 103–106 (1984).

    Article  CAS  Google Scholar 

  17. Murzin, A.G., Brenner, S.E., Hubbard, T. & Chothia, C. J. Mol. Biol. 247, 536–540 (1995).

    CAS  Google Scholar 

  18. Richardson, J.S., Richardson, D.C., Thomas, K.A., Silverton, E.W. & Davies, D.R. J. Mol. Biol. 102, 221–235 (1976).

    Article  CAS  Google Scholar 

  19. Holm, L. & Sander, C. J. Mol. Biol. 233, 123–138 (1993).

    Article  CAS  Google Scholar 

  20. Silence, K. et al. J. Biol. Chem. 270, 27192–27195 (1995).

    Article  CAS  Google Scholar 

  21. Schlott, B. et al. Biochim. Biophys. Acta 1204, 235–242 (1994).

    Article  CAS  Google Scholar 

  22. Reid, K.S.C., Lindley, P.F. & Thornton, J.M. FEBS Letts. 190, 209–213 (1985).

    Article  CAS  Google Scholar 

  23. Jin, L., Fendly, B.M. & Wells, J.A. J. Mol. Biol. 226, 851–865 (1992).

    Article  CAS  Google Scholar 

  24. Collen, D. et al. Circulation 94, 197–206 (1996).

    Article  CAS  Google Scholar 

  25. Rabijns, A., Baeyens, K., De Bondt, H.L. & De Ranter, C. Proteins. 27, 160–161 (1997).

    Article  CAS  Google Scholar 

  26. Otwinowski, Z. Oscillation data reduction program. in Proceedings of the CCP4 study weekend: Data collection and processing (eds Sawyer, L, Isaacs, N. & Bailey, S.) 56–62 (SERC Daresbury Laboratory, England, 1993).

    Google Scholar 

  27. Furey, W. & Swaminathan, S. Am. Crystallogr. Assoc. Meet. Abstr. 18 (PA33)73 (1990).

    Google Scholar 

  28. Jones, T.A., Zhou, J.Y., Cowan, S.W. & Kjelgaard, M. Acta Crystallogr. A47, 110–119 (1991).

    Article  CAS  Google Scholar 

  29. Claessens, M., Van Cutsem, E., Lasters, I. & Wodak, S. Prot. Eng. 2, 335–345 (1989).

    Article  CAS  Google Scholar 

  30. Desmet, J., De Maeyer, M., Hazes, B. & Lasters, I. Nature 356, 539–542 (1992).

    Article  CAS  Google Scholar 

  31. De Maeyer, M., Desmet, J. & Lasters, I. Folding & Design 2, 53–66 (1997).

    Article  CAS  Google Scholar 

  32. Brünger, A.T., Kuriyan, J. & Karplus, M. Science 235, 458–460 (1987)

    Article  Google Scholar 

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Rabijns, A., De Bondt, H. & De Ranter, C. Three-dimensional structure of staphylokinase, a plasminogen activator with therapeutic potential. Nat Struct Mol Biol 4, 357–360 (1997). https://doi.org/10.1038/nsb0597-357

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