The three-dimensional structure of staphylokinase has been determined at 1.8 Å.The puntative site of interaction with plasminogen was identified and epitopes were mapped.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Structure-based antigenic epitope and PEGylation improve the efficacy of staphylokinase
Microbial Cell Factories Open Access 14 November 2017
-
Staphylokinase has distinct modes of interaction with antimicrobial peptides, modulating its plasminogen-activation properties
Scientific Reports Open Access 24 August 2016
-
Small but versatile: the extraordinary functional and structural diversity of the β-grasp fold
Biology Direct Open Access 02 July 2007
Access options
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Lack, C.H. Nature 161, 559–560 (1948).
Collen, D. & Van de Werf, F. Circulation 87, 1850–1852 (1993).
Vanderschueren, S. et al. Circulation 92, 2044–2049 (1995)
Gase, A. et al. Eur. J. Biochem. 223, 303–308 (1994).
Collen, D., De Mol, M., Demarsin, E., De Cock, F. & Stassen, J.M. Fibrinolysis 7, 242–247 (1993).
Schlott, B. et al. BiolTechnology 12, 185–189 (1994)
Collen, D. et al. J. Biol. Chem. 268, 8284–8289 (1993)
Lijnen, H.R. et al. J. Biol. Chem. 266, 11826–11832 (1991)
Damaschun, G. et al. Biochim. Biophys. Acta 1161, 244–248 (1993).
Silence, K., Collen, D. & Lijnen, H.R. Blood 3, 605–614 (1992).
Hauptmann, J. & Glusa, E. Blood Coag. Fibrinol. 6, 579–583 (1995).
Collen, D., De Cock, F. & Stassen, J.M. Circulation 87, 996–1006 (1993).
Stassen, J.M., Nyström, Å., Hoylaerts, M. & Collen, D. Circulation 91, 1330–1335 (1995).
Vanderschueren, S., Stassen, J.M. & Collen, D. Thromb. Haemost. 72, 297–301 (1994).
Boutonnet, N.S., Rooman, M.J., Ochagavia, M.E., Richelle, J. & Wodak, S.J. Prot Eng. 8, 647–662 (1995).
Delhaise, P., Bardiaux, M. & Wodak, S. J. Mol. Graph. 2, 103–106 (1984).
Murzin, A.G., Brenner, S.E., Hubbard, T. & Chothia, C. J. Mol. Biol. 247, 536–540 (1995).
Richardson, J.S., Richardson, D.C., Thomas, K.A., Silverton, E.W. & Davies, D.R. J. Mol. Biol. 102, 221–235 (1976).
Holm, L. & Sander, C. J. Mol. Biol. 233, 123–138 (1993).
Silence, K. et al. J. Biol. Chem. 270, 27192–27195 (1995).
Schlott, B. et al. Biochim. Biophys. Acta 1204, 235–242 (1994).
Reid, K.S.C., Lindley, P.F. & Thornton, J.M. FEBS Letts. 190, 209–213 (1985).
Jin, L., Fendly, B.M. & Wells, J.A. J. Mol. Biol. 226, 851–865 (1992).
Collen, D. et al. Circulation 94, 197–206 (1996).
Rabijns, A., Baeyens, K., De Bondt, H.L. & De Ranter, C. Proteins. 27, 160–161 (1997).
Otwinowski, Z. Oscillation data reduction program. in Proceedings of the CCP4 study weekend: Data collection and processing (eds Sawyer, L, Isaacs, N. & Bailey, S.) 56–62 (SERC Daresbury Laboratory, England, 1993).
Furey, W. & Swaminathan, S. Am. Crystallogr. Assoc. Meet. Abstr. 18 (PA33)73 (1990).
Jones, T.A., Zhou, J.Y., Cowan, S.W. & Kjelgaard, M. Acta Crystallogr. A47, 110–119 (1991).
Claessens, M., Van Cutsem, E., Lasters, I. & Wodak, S. Prot. Eng. 2, 335–345 (1989).
Desmet, J., De Maeyer, M., Hazes, B. & Lasters, I. Nature 356, 539–542 (1992).
De Maeyer, M., Desmet, J. & Lasters, I. Folding & Design 2, 53–66 (1997).
Brünger, A.T., Kuriyan, J. & Karplus, M. Science 235, 458–460 (1987)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Rabijns, A., De Bondt, H. & De Ranter, C. Three-dimensional structure of staphylokinase, a plasminogen activator with therapeutic potential. Nat Struct Mol Biol 4, 357–360 (1997). https://doi.org/10.1038/nsb0597-357
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/nsb0597-357
This article is cited by
-
Structure-based antigenic epitope and PEGylation improve the efficacy of staphylokinase
Microbial Cell Factories (2017)
-
Staphylokinase has distinct modes of interaction with antimicrobial peptides, modulating its plasminogen-activation properties
Scientific Reports (2016)
-
High-level expression of non-glycosylated and active staphylokinase from Pichia pastoris
Biotechnology Letters (2009)
-
Small but versatile: the extraordinary functional and structural diversity of the β-grasp fold
Biology Direct (2007)
-
The ternary microplasmin–staphylokinase–microplasmin complex is a proteinase–cofactor–substrate complex in action
Nature Structural Biology (1998)