Abstract
Post-translational modifications of proteins and the domains that recognize these modifications have central roles in creating a highly dynamic relay system that reads and responds to alterations in the cellular microenvironment. Here we review the common principles of post-translational modifications and their importance in signal integration underlying epidermal growth factor receptor signaling and endocytosis, DNA-damage responses and immunity.
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Deribe, Y., Pawson, T. & Dikic, I. Post-translational modifications in signal integration. Nat Struct Mol Biol 17, 666–672 (2010). https://doi.org/10.1038/nsmb.1842
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DOI: https://doi.org/10.1038/nsmb.1842
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