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Barreling through the membrane

The mechanism of transmembrane β-barrel protein insertion into an intracellular membrane is essentially unknown. Two recent studies reveal that the process is protein-mediated and identify a protein complex that is involved.

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Figure 1: Pathways for polypeptide insertion into membranes.

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Johnson, A., Jensen, R. Barreling through the membrane. Nat Struct Mol Biol 11, 113–114 (2004). https://doi.org/10.1038/nsmb0204-113

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