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Rings around kinetochore microtubules in yeast

Nature Structural & Molecular Biology volume 12, pages 210–212 (2005)Cite this article

Two recent papers characterize a protein complex that is part of the budding yeast kinetochore, the specialization that links chromosomal DNA with one or more spindle microtubules. Both studies present convincing evidence that this complex can assemble into rings or helices that wrap around microtubules.

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Figure 1: Diagrams of chromosome-MT attachment during mitosis.

E. Boyle

Figure 2: Serial slices from an electron tomogram that reconstructs the plus-end of a yeast kinetochore MT.

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Acknowledgements

I thank M. Winey, K. Grishchuk, R. West and E. O'Toole for thoughtful readings of this manuscript. E. O'Toole provided the data for Figure 2. Support from the US National Institutes of Health (GM 33787, P01061306 and RR00592) and from the American Cancer Society is gratefully acknowledged.

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  1. the Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, 80309-0347, Colorado, USA

    J Richard McIntosh

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McIntosh, J. Rings around kinetochore microtubules in yeast. Nat Struct Mol Biol 12, 210–212 (2005). https://doi.org/10.1038/nsmb0305-210

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