Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Bow to your partner for signaling

Nature Structural & Molecular Biology volume 12, pages 476–478 (2005)Cite this article

A recent study on the signaling conformation of the common receptor for the interleukin-6 family of cytokines, gp130, provides new insights into the activation mechanism of the 'tall' cytokine receptors.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Schematic depiction of the tall signaling receptor subunits of the IL-6/IL-12 family of cytokines.
Figure 2: Comparison of the receptor complexes for Epo and IL-6.

References

  1. Ballinger, M.D. & Wells, J.A. Nat. Struct. Biol. 5, 938–940 (1998).

    Article  CAS  Google Scholar 

  2. Skiniotis, G., Boulanger, M.J., Garcia, K.C. & Walz, T. Nat. Struct. Mol. Biol. 12, 545–551 (2005).

    Article  CAS  Google Scholar 

  3. Syed, R.S. et al. Nature 395, 511–516 (1998).

    Article  CAS  Google Scholar 

  4. Livnah, O. et al. Science 283, 987–990 (1999).

    Article  CAS  Google Scholar 

  5. Boulanger, M.J., Chow, D.C., Brevnova, E.E. & Garcia, K.C. Science 300, 2101–2104 (2003).

    Article  CAS  Google Scholar 

  6. Kurth, I. et al. J. Immunol. 164, 273–282 (2000).

    Article  CAS  Google Scholar 

  7. Aritomi, M. et al. Nature 401, 713–717 (1999).

    Article  CAS  Google Scholar 

  8. Layton, J.E., Hall, N.E., Connell, F., Venhorst, J. & Treutlein, H.R. J. Biol. Chem. 276, 36779–36787 (2001).

    Article  CAS  Google Scholar 

  9. Hammacher, A. et al. Biochem. J. 345, 25–32 (2000).

    Article  CAS  Google Scholar 

  10. Livnah, O. et al. Science 273, 464–471 (1996).

    Article  CAS  Google Scholar 

  11. Livnah, O. et al. Nat. Struct. Biol. 5, 993–1004 (1998).

    Article  CAS  Google Scholar 

  12. Constantinescu, S.N., Huang, L.J., Nam, H. & Lodish, H.F. Mol. Cell 7, 377–385 (2001).

    Article  CAS  Google Scholar 

  13. Greiser, J.S., Stross, C., Heinrich, P.C., Behrmann, I. & Hermanns, H.M. J. Biol. Chem. 277, 26959–26965 (2002).

    Article  CAS  Google Scholar 

  14. Schroers, A. et al. Protein Sci. 14, 783–790 (2005).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institut für Biochemie, Universitätsklinikum der RWTH Aachen, Pauwelsstrasse 30, Aachen, 52074, Germany

    Heike M Hermanns, Gerhard Müller-Newen, Peter C Heinrich & Serge Haan

Authors
  1. Heike M Hermanns
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Gerhard Müller-Newen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Peter C Heinrich
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Serge Haan
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hermanns, H., Müller-Newen, G., Heinrich, P. et al. Bow to your partner for signaling. Nat Struct Mol Biol 12, 476–478 (2005). https://doi.org/10.1038/nsmb0605-476

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsmb0605-476

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing