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Combinatorial control of gene expression

Nature Structural & Molecular Biology volume 11, pages 812–815 (2004)Cite this article

Abstract

Revealing the molecular principles of eukaryotic transcription factor assembly on specific DNA sites is pivotal to understanding how genes are differentially expressed. By analyzing structures of transcription factor complexes bound to specific DNA elements we demonstrate how protein and DNA regulators manage gene expression in a combinatorial fashion.

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Figure 1: Examples of transcription factor–DNA complexes involved in combinatorial control of gene expression.
Figure 2: Importance of DNA site architecture in POU factor–mediated gene expression regulation.
Figure 3: Interaction diagram of Oct-1 and Sox-2.

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Author notes

  1. Attila Reményi

    Present address: Department of Cellular and Molecular Pharmacology, University of California, San Francisco, 600 16th Street, San Francisco, California, 94143-2240, USA

Authors and Affiliations

  1. Gene Expression Program, European Molecular Biology Laboratory, Heidelberg, 69117, Germany

    Attila Reményi & Hans R Schöler

  2. European Molecular Biology Laboratory, Hamburg Outstation, Notkestrasse 85, Hamburg, D-22603, Germany

    Attila Reményi & Matthias Wilmanns

  3. Department of Cell and Developmental Biology, Max-Planck-Institute for Molecular Biomedicine, Mendelstrasse 7, Münster, 48149, Germany

    Hans R Schöler

Authors
  1. Attila Reményi
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  3. Matthias Wilmanns
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Correspondence to Attila Reményi.

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The authors declare no competing financial interests.

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Reményi, A., Schöler, H. & Wilmanns, M. Combinatorial control of gene expression. Nat Struct Mol Biol 11, 812–815 (2004). https://doi.org/10.1038/nsmb820

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