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SRP meets the ribosome

Nature Structural & Molecular Biology volume 11, pages 1049–1053 (2004)Cite this article

Abstract

Cotranslational targeting directly couples synthesis of proteins to their translocation across or insertion into membranes. The signal recognition particle (SRP) and its membrane-bound receptor facilitate the targeting of the translation machinery, the ribosome, via recognition of a signal sequence in the nascent peptide chain. By combining structures of free and ribosome-bound SRP we derive a structural model describing the dynamic nature of SRP when it meets the ribosome.

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Figure 1: Cotranslational targeting by the SRP system.
Figure 2: Conformational changes of the SRP core.
Figure 3: Model for the first steps of the SRP cycle.

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Acknowledgements

We acknowledge support by European Union (EU) network grant QLK-CT2000-00082 and by the Deutsche Forschungsgemeinschaft (SFB 638) to I.S., by the VolkswagenStiftung, the EU and Senatsverwaltung für Wissenschaft, Forschung und Kultur Berlin, in the context of the Ultra-Structure Network and the Deutsche Forschungsgemeinschaft (SFB 449) to R.B.

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  1. Klemens Wild and Mario Halic: These authors contributed equally to this work.

Authors and Affiliations

  1. Biochemie-Zentrum der Universität Heidelberg (BZH), Im Neuenheimer Feld 328, Heidelberg, D-69120, Germany

    Klemens Wild & Irmgard Sinning

  2. Insitute of Biochemistry, Charité, University Medical School Berlin, Monbijoustrasse 2, Berlin, D-10117, Germany

    Mario Halic & Roland Beckmann

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  1. Klemens Wild
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Correspondence to Roland Beckmann.

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Wild, K., Halic, M., Sinning, I. et al. SRP meets the ribosome. Nat Struct Mol Biol 11, 1049–1053 (2004). https://doi.org/10.1038/nsmb853

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