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FOXO-binding partners: it takes two to tango

Oncogene volume 27, pages 2289–2299 (2008)Cite this article

Abstract

Modulation FOXO transcription factor activities can lead to a variety of cellular outputs resulting in changes in proliferation, apoptosis, differentiation and metabolic responses. Although FOXO proteins all contain an identical DNA-binding domain their cellular functions appear to be distinct, as exemplified by differences in the phenotype of Foxo1, Foxo3 and Foxo4 null mutant mice. While some of these differences may be attributable to the differential expression patterns of these transcription factors, many cells and tissues express several FOXO isoforms. Recently it has become clear that FOXO proteins can regulate transcriptional responses independently of direct DNA-binding. It has been demonstrated that FOXOs can associate with a variety of unrelated transcription factors, regulating activation or repression of diverse target genes. The complement of transcription factors expressed in a particular cell type is thus critical in determining the functional end point of FOXO activity. These interactions greatly expand the possibilities for FOXO-mediated regulation of transcriptional programmes. This review details currently described FOXO-binding partners and examines the role of these interactions in regulating cell fate decisions.

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Article Open access 27 October 2023

Bruno F. Santos, Inês Grenho, … Wolfgang Link

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Acknowledgements

Kristan van der Vos was supported by a grant from the Dutch Scientific Organization (NWO 917.36.316).

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  1. Department of Immunology, Molecular Immunology Lab, Wilhelmina Children's Hospital, University Medical Center, Utrecht, The Netherlands

    K E van der Vos & P J Coffer

  2. Department of Pediatric Immunology, Wilhelmina Children's Hospital, University Medical Center, Utrecht, The Netherlands

    P J Coffer

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van der Vos, K., Coffer, P. FOXO-binding partners: it takes two to tango. Oncogene 27, 2289–2299 (2008). https://doi.org/10.1038/onc.2008.22

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