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PI3K/Akt: getting it right matters

Abstract

The Akt serine/threonine kinase (also called protein kinase B) has emerged as a critical signaling molecule within eukaryotic cells. Significant progress has been made in clarifying its regulation by upstream kinases and identifying downstream mechanisms that mediate its effects in cells and contribute to signaling specificity. Here, we provide an overview of present advances in the field regarding the function of Akt in physiological and pathological cell function within a more generalized framework of Akt signal transduction. An emphasis is placed on the involvement of Akt in human diseases ranging from cancer to metabolic dysfunction and mental disease.

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Acknowledgements

Work on the Akt signaling cascade in Dr Franke's laboratory is supported by the National Science Foundation (NSF award IOS-0757780), the National Institutes of Health (grant RO1MH079439), Susan G Komen for the Cure and the G Harold & Leila Y Mathers Foundation. I thank Alexander Broad and Andrew Sideris for assistance with the Akt signaling schematics, and Terry McIntosh for diligent production of this manuscript.

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Correspondence to T F Franke.

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Franke, T. PI3K/Akt: getting it right matters. Oncogene 27, 6473–6488 (2008). https://doi.org/10.1038/onc.2008.313

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