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Up for Mischief? IL-17/Th17 in the tumour microenvironment

Oncogene volume 29, pages 5653–5662 (2010)Cite this article

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Abstract

The role of interleukin (IL)-17 and the IL-17-producing T helper (Th)17 cells in cancer has recently become the focus of extensive investigation. An expanding body of literature implicates Th17 cells and their hallmark cytokine in both pro- and anti-tumourigenic processes. In this review we describe their biological activities and outline the reciprocal interactions between Th17 cells and other cells of the immune system. We also discuss the evidence regarding their dual role in the tumour microenvironment. An understanding of the processes that regulate the pro- or anti-tumour activities of Th17 cell and IL-17 will allow the development of more effective means for cancer immunotherapy.

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Acknowledgements

This work was supported by the Medical Research Council (to T Hagemann and R Soper) and Cancer Research UK (to T Hagemann and E Maniati).

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  1. Centre for Cancer and Inflammation, Institute of Cancer, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK

    E Maniati, R Soper & T Hagemann

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Maniati, E., Soper, R. & Hagemann, T. Up for Mischief? IL-17/Th17 in the tumour microenvironment. Oncogene 29, 5653–5662 (2010). https://doi.org/10.1038/onc.2010.367

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  • DOI: https://doi.org/10.1038/onc.2010.367

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