Summary
Experimental studies suggest that the risk of prostate cancer is reduced with the intake of long-chain n-3 polyunsaturated fatty acids derived from marine foods, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). However, few human studies have been conducted due to difficulties in assessing the dietary intake of these fatty acids. The authors examined the relationship between prostate cancer risk and EPA and DHA in erythrocyte biomarkers in a population-based case–control study in Auckland, New Zealand during 1996–1997 involving 317 prostate cancer cases and 480 age-matched community controls. Reduced prostate cancer risk was associated with high erythrocyte phosphatidylcholine levels of EPA (multivariate relative risk = 0.59; 95% confidence interval 0.37–0.95, upper vs lowest quartile) and DHA (multivariate relative risk = 0.62; 95% confidence interval 0.39–0.98, upper vs lowest quartile). These analyses support evidence from in vitro experiments for a reduced risk of prostate cancer associated with dietary fish oils, possibly acting via inhibition of arachidonic acid-derived eicosanoid biosynthesis.
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References
Agren, JJ & Hanninen, OO (1991). Effect of moderate freshwater fish diet on erythrocyte ghost phospholipid fatty acids. Ann Med 23: 261–263.
Baro, L, Hermoso, J-C, Nunez, M-C, Jiminenez-Rios, J-A & Gil, A (1998). Abnormalities in plasma and red blood cell fatty acid profiles of patients with colorectal cancer. Br J Cancer 77: 1978–1983.
Bligh, DG & Dyer, WJ (1959). A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37: 911–917.
Brown, AJ, Pang, E & Roberts, DC (1991). Persistent changes in the fatty acid composition of erythrocyte membrance after moderate intake of n-3 polyunsaturated fatty acids: study design implications. Am J Clin Nutr 54: 668–673.
Burlingame, BA, Milligan, GC, Apimerika, DE & Arthur, JM (1993). The Concise New Zealand Food Composition Tables. New Zealand Institute for Crop and Food Research Limited, Department of Health: Palmerston North, NZ
Chaudry, AA, Wahle, KWJ, McClinton, S & Moffat, LEP (1994). Arachidonic acid metabolism in benign and malignant prostatic tissue in vitro: effects of fatty acids and cyclooxygenase inhibitors. Int J Cancer 57: 176–180.
Earnest, DL, Hixson, LJ & Alberts, DS (1992). Piroxicam and other cyclooxygenase inhibitors: potential for cancer chemoprevention. J Cell Biochem 161, (suppl) 156–166.
Ewings, P & Bowie, C (1996). A case–control study of cancer of the prostate in Somerset and East Devon. Br J Cancer 74: 661–666.
Gann, PH, Hennekens, FM, Sacks, FG, Grodstein, F, Giovannucci, EL & Stampfer, MJ (1994). Prospective study of plasma fatty acids and risk of prostate cancer. J Natl Cancer Inst 86: 281–286.
Giovannucci, E (1995). Epidemiological characteristics of prostate cancer. Cancer 75: 1766–1777.
Giovannucci, E, Rimm, EB, Colditz, GA, Stampfer, MJ, Asherio, A, Chute, CC & Willett, WC (1992). A prospective study of dietary fat and risk of prostate cancer. J Natl Cancer Inst 85: 1571–1579.
Glatz, JFC, Soffers, AE & Katan, MB (1989). Fatty acid composition of serum cholesterol esters and erythrocyte membranes as indicators of linoleic acid intake in man. Am J Clin Nutr 49: 269–276.
Godley, PA, Campbell, MK, Miller, C, Gallagher, P, Martinson, FE, Mohler, JL & Sandler, RS (1996a). Correlation between biomarkers of omega-3 fatty acid consumption and questionnaire data in African American and Caucasian United States males with and without prostatic carcinoma. Cancer Epidemiol Biomarkers Prev 5: 115–119.
Godley, PA, Campbell, MK, Gallagher, P, Martinson, FEA, Mohler, JL & Sandler, RS (1996b). Biomarkers of essential fatty acid consumption and risk of prostatic carcinoma. Cancer Epidemiol Biomarkers Prev 5: 889–895.
Harvei, S, Bjerve, KS, Tretli, S, Jellum, E, Robsahm, TE & Vatten, L (1997). Prediagnostic level of fatty acids in serum phospholipids: Ω-3 and Ω-6 fatty acids and the risk of prostate cancer. Int J Cancer 71: 545–551.
Holub, BJ & Skeaff, CM (1987). Nutritional regulation of cellular phosphatidylinositol. Methods Enzymol 141: 234–244.
Johnston, R (1983). A Revision of Socio-economic Indices for New Zealand. New Zealand Council for Educational Research: Wellington
Karmali, RA (1987). Fatty acids: inhibition. Am J Clin Nutr 45: 225–229.
Kolonel, LN (1996). Nutrition and prostate cancer. Cancer Causes Control 7: 83–94.
Lupulescu, A (1996). Prostaglandins, their inhibitors and cancer. Prostaglandins Leuko Essent Fatty Acids 54: 83–94.
Mishina, T, Watanabe, H, Araki, H & Nakao, M (1985). Epidemiological study of prostatic cancer by matched pair analysis. Prostate 6: 423–436.
Mantzioris, E, James, MJ, Gibson, RA & Cleland, LG (1994). Dietary substitution with an alpha-linolenic acid-rich vegetable oil increases eicosapentaenoic acid concentrations in tissues. Am J Clin Nutr 59: 1304–1309.
Nomura, AM & Kolonel, LN (1991). Prostate cancer: a current perspective. Am J Epidemiol 139: 200–227.
Norrish, AE, Jackson, RT & McRae, CU (1998). Non-steroidal anti-inflammatory drugs and prostate cancer progression. Int J Cancer 77: 511–515.
Pandalai, PK, Pilat, MJ, Yamazaki, K, Naik, H & Pienta, KJ (1996). The effects of omega-3 and omega-6 fatty acids on in vitro prostate cancer growth. Anticancer Res 16: 815–820.
Rose, DP (1997). Effects of dietary fatty acids on breast and prostate cancers: evidence from in vitro experiments and animal studies. Am J Clin Nutr 66, (suppl) 1513S–1522S.
Rose, DP & Connolly, JM (1991). Effects of fatty acids and eicosanoid synthesis on the growth of two prostate cancer cell lines. Prostate 18: 243–254.
Sanders, TA & Roshanai, F (1983). The influence of different types of omega 3 polyunsaturated fatty acids on blood lipids and platelet function in healthy volunteers. Clinical Science 64: 91–99.
Sharpe, SJ, Page, NA, Gamble, GD & Sharpe, CM (1993). Validation of a food frequency questionnaire for use in cardiovascular risk factor studies in New Zealand. Proc Nut Soc NZ 18: 90–100.
Vajreswari, A & Narayanareddy, K (1992). Effect of dietary fats on erythrocyte membrane lipid composition and membrane-bound enzyme activities. Metabolism 41: 352–358.
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Norrish, A., Skeaff, C., Arribas, G. et al. Prostate cancer risk and consumption of fish oils: A dietary biomarker-based case–control study. Br J Cancer 81, 1238–1242 (1999). https://doi.org/10.1038/sj.bjc.6690835
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DOI: https://doi.org/10.1038/sj.bjc.6690835
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