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Toxic epidermal necrolysis: differential diagnosis of an epidermolytic dermopathy in a hematopoietic stem cell transplant recipient

Bone Marrow Transplantation volume 30, pages 331–333 (2002)Cite this article

Abstract

Toxic epidermal necrolysis (TEN) is an epidermolytic skin disorder associated with drug administration. It is associated with an erythematous rash with full thickness epidermal loss and characteristic histology. A 35-year-old woman underwent allogeneic hematopoietic stem cell transplantation (HSCT) for severe aplastic anemia (SAA). She developed an acute epidermolytic rash and TEN was diagnosed on the basis of skin biopsy. In the HSCT setting, TEN should be thought of as an important differential diagnosis of epidermolytic dermopathies. The most distinctive diagnostic test in the differential diagnosis of these disorders is skin biopsy

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References

  1. Mockenhaupt M, Schoepf E . Epidemiology of drug-induced severe skin reactions Sem Cutan Med Surg 1996 15: 236 243

    Article  CAS  Google Scholar 

  2. Wintroub BU, Stern R . Cutaneous drug reactions: pathogenesis and clinical classification J Am Acad Dermatol 1985 13: 167 179

    Article  CAS  Google Scholar 

  3. Revuz JE, Roujeau JC . Advances in toxic epidermal necrolysis Sem Cutan Med Surg 1996 15: 258 266

    Article  CAS  Google Scholar 

  4. Schwartz RA . Toxic epidermal necrolysis Cutis 1997 59: 123 128

    CAS  PubMed  Google Scholar 

  5. Sluysmans T, De Bont B, Cornu G . Acute epidermal necrolysis or Lyell syndrome Eur J Pediatr 1987 146: 199 200

    Article  CAS  Google Scholar 

  6. Ladhani S, Joannou CL, Lochrie DP et al. Clinical, microbial and biochemical aspects of the exfoliative toxins causing staphylococcal scalded skin syndrome Clin Microbiol Rev 1999 12: 224 242

    Article  CAS  Google Scholar 

  7. Avakian R, Flowers FP, Araujo OE et al. Toxic epidermal necrolysis: a review J Am Acad Dermatol 1991 25: 69 79

    Article  CAS  Google Scholar 

  8. Roujeau JC, Chosidow O, Saiag P et al. Toxic epidermal necrolysis (Lyell syndrome) J Am Acad Dermatol 1990 23: 1039 1058

    Article  CAS  Google Scholar 

  9. Roujeau JC . Treatment of severe drug eruptions J Dermatol 1999 26: 718 722

    Article  CAS  Google Scholar 

  10. Friedman HZ, Arias AM, Catchatourian R et al. Toxic epidermal necrolysis following bone marrow transplantation Cutis 1984 43: 158 162

    Google Scholar 

  11. Villada G, Roujeau JC, Cordonnier C et al. Toxic epidermal necrolysis after bone marrow transplantation: study of nine cases J Am Acad Dermatol 1990 23: 870 875

    Article  CAS  Google Scholar 

  12. Revuz J, Penso D, Roujeau JC et al. Toxic epidermal necrolysis. Clinical findings and prognosis factors in 87 patients Arch Dermatol 1987 123: 1160 1165

    Article  CAS  Google Scholar 

  13. Craven NM . Management of toxic epidermal necrolysis Hosp Med 2000 61: 778 781

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Bone Marrow Transplantation Center Idar-Oberstein, Germany

    JL Zakrzewski, G Lentini, U Such, A Duerr, V Tran, S Guenzelmann & M Koldehoff

  2. Department of Pathology, University of Freiburg, Germany

    T Braunschweig & UN Riede

Authors
  1. JL Zakrzewski
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  2. G Lentini
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  3. U Such
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  4. A Duerr
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  5. V Tran
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  6. S Guenzelmann
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  7. T Braunschweig
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  8. UN Riede
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  9. M Koldehoff
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Zakrzewski, J., Lentini, G., Such, U. et al. Toxic epidermal necrolysis: differential diagnosis of an epidermolytic dermopathy in a hematopoietic stem cell transplant recipient. Bone Marrow Transplant 30, 331–333 (2002). https://doi.org/10.1038/sj.bmt.1703624

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  • DOI: https://doi.org/10.1038/sj.bmt.1703624

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