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Transfer of the hematopoietic stem cell transplant patient to the intensive care unit: does it really matter?

Bone Marrow Transplantation volume 37, pages 119–133 (2006)Cite this article

Abstract

We critically reviewed published English language literature and concluded that from 1998 onward the survival of hematopoietic stem cell transplant (SCT) patients who experienced intensive care unit (ICU) transfer has improved. The factors associated with increased mortality during ICU stay included increased patient age, allogeneic transplant, intubation/mechanical ventilation, multiorgan system failure (MOSF), presumed/documented infection, graft-versus-host disease, and higher APACHE and O-PRISM score at ICU transfer. This encouraging outcome trend reflects evolving advances such as use of recombinant hematopoietic growth factors, use of mobilized blood cells rather than marrow, protective strategies for acute lung injury and early goal-directed therapy for sepsis syndrome. Patient selection bias (which patients were transferred and which were not sent to an ICU) also plays a role in ICU survival rates. New strategies to improve upon SCT patient outcome include use of a scoring system to predict mortality, better therapies for MOSF and integration of ICU components and multispecialist involvement earlier in the clinical course to prevent severe complications such as respiratory failure. SCT recipients comprise a heterogeneous group; to further advance this field, prospective multicenter trials involving larger populations from many centers are needed to reduce the biases of retrospective and single-center reports.

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Acknowledgements

Dr Reed's contribution to this work was supported, in part, by a Pediatric Pharmacology Research Unit Grant from the National Institute of Child Health and Development (HD31323-12).

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Authors and Affiliations

  1. Department of Medicine, Divisions of Hematology-Oncology and Pulmonary/Critical Care, Cleveland, OH, USA

    N Naeem, R J Creger & H M Lazarus

  2. Department of Pediatrics, Division of Pediatric Pharmacology and Critical Care, Cleveland, OH, USA

    M D Reed

  3. Department of Psychiatry, University Hospitals of Cleveland, Rainbow Babies and Childrens Hospital, and the Comprehensive Cancer Center of Case Western Reserve University, Cleveland, OH, USA

    S J Youngner

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Correspondence to H M Lazarus.

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Naeem, N., Reed, M., Creger, R. et al. Transfer of the hematopoietic stem cell transplant patient to the intensive care unit: does it really matter?. Bone Marrow Transplant 37, 119–133 (2006). https://doi.org/10.1038/sj.bmt.1705222

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