Abstract
Regulation of the p53 tumor suppressor protein occurs to a large extent through control of protein stability, and the MDM2 protein has been shown to play a key role in targeting p53 for degradation. Stress signals that activate the p53 response lead to stabilization of p53 through inhibition of MDM2 mediated degradation, and it is becoming evident that a number of mechanisms exist to abrogate this activity of MDM2. Other members of the p53 protein family may also be regulated through protein stability, although MDM2 is not responsible for the degradation of p73. Nevertheless, interactions of p63 and p73 with MDM2 or p53 have been described, suggesting that each of the p53-related proteins can play some role in regulating the activity of the others
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
Corresponding author
Additional information
Edited by R Knight
Rights and permissions
About this article
Cite this article
Lohrum, M., Vousden, K. Regulation and activation of p53 and its family members. Cell Death Differ 6, 1162–1168 (1999). https://doi.org/10.1038/sj.cdd.4400625
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.cdd.4400625
Keywords
This article is cited by
-
α-Synucleinopathy associated c-Abl activation causes p53-dependent autophagy impairment
Molecular Neurodegeneration (2020)
-
Novel Mannich base 3FB3FA8H induces apoptosis by upregulating P53 pathway in neuroblastoma cells
Molecular and Cellular Biochemistry (2020)
-
Towards reconstructing the dipteran demise of an ancient essential gene: E3 ubiquitin ligase Murine double minute
Development Genes and Evolution (2020)
-
Chemoprevention by Probiotics During 1,2-Dimethylhydrazine-Induced Colon Carcinogenesis in Rats
Digestive Diseases and Sciences (2018)
-
Co-expression of POU4F2/Brn-3b with p53 may be important for controlling expression of pro-apoptotic genes in cardiomyocytes following ischaemic/hypoxic insults
Cell Death & Disease (2014)