Abstract
Objective: To determine the effect of a biscuit with red palm oil as a source of β-carotene on the vitamin A status of primary school children and to compare this with the effect of a biscuit with β-carotene from a synthetic source.
Design: Randomised controlled trial.
Setting: A rural community in KwaZulu-Natal, South Africa.
Subjects: A total of 437 primary school children, aged 5–11 y; 400 completed the study.
Intervention: Subjects were randomly assigned to one of three groups, receiving, respectively: (i) a placebo biscuit; (ii) a biscuit with synthetic β-carotene as a vitamin A fortificant (SB); (iii) a biscuit with red palm oil as a source of β-carotene (PB); SB and PB supplied 30% of the RDA for vitamin A per serving of three biscuits. Biscuits were distributed daily during the school week; vitamin A status was assessed at baseline and after 3 months.
Results: There was a significant improvement in serum retinol compared to the control group in both the SB and PB groups (P<0.005); the treatment effect for the two groups was equivalent (difference in treatment effect 0.62 µg/dl, with a 90% CI−0.33–1.57).
Conclusions: A biscuit with red palm oil as a source of β-carotene is as effective as a biscuit with synthetic β-carotene in improving the vitamin A status of primary school children. The additional qualities of red palm oil (ie no trans fatty acids; rich source of antioxidants) make it an excellent alternative fortificant for addressing vitamin A deficiency.
Sponsorship: Financial support from Palm Oil Research Institute of Malaysia (PORIM).
European Journal of Clinical Nutrition (2001) 55, 657–662
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Acknowledgements
We thank Eldrich Harmse, Martelle Marais and De Wet Marais for their excellent technical support; the Department of Haematology, University of Natal for performing the full blood counts; the headmasters, staff and pupils of the Ndunakazi and Intongela Primary Schools for their friendly co-operation; the team of nutrition monitors for their invaluable support and dedication to the study; Nonnie Vorster from SASKO Pty Ltd for formulating the recipe of the biscuits; Bud's Biscuits for baking and delivering the biscuits; and Global Palm Products SDN, BHD for supplying the refined red palm oil.
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van Stuijvenberg, M., Dhansay, M., Lombard, C. et al. The effect of a biscuit with red palm oil as a source of β-carotene on the vitamin A status of primary school children: a comparison with β-carotene from a synthetic source in a randomised controlled trial. Eur J Clin Nutr 55, 657–662 (2001). https://doi.org/10.1038/sj.ejcn.1601196
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DOI: https://doi.org/10.1038/sj.ejcn.1601196
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