Abstract
DNA samples from 396 unrelated individuals belonging to 14 ethnic populations of India, inhabiting various geographical locations and occupying various positions in the socio-cultural hierarchy, were analysed in respect of 8 human-specific polymorphic insertion/deletion loci. All loci, except Alu CD4, were found to be highly polymorphic in all populations. The levels of average heterozygosities were found to be very high in all populations and, in most populations, also higher than those predicted by the island model of population structure. The coefficient of gene differentiation among Indian populations was found to be higher than populations in most other global regions, except Africa. These results are discussed in the light of two possible scenarios of evolution of Indian populations in the broader context of human evolution.
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Majumder, P., Roy, B., Banerjee, S. et al. Human-specific insertion/deletion polymorphisms in Indian populations and their possible evolutionary implications. Eur J Hum Genet 7, 435–446 (1999). https://doi.org/10.1038/sj.ejhg.5200317
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.ejhg.5200317
Keywords
This article is cited by
-
APOE, MTHFR, LDLR and ACE Polymorphisms Among Angami and Lotha Naga Populations of Nagaland, India
Journal of Community Health (2011)
-
Haplotype variation in the ACE gene in global populations, with special reference to India, and an alternative model of evolution of haplotypes
The HUGO Journal (2011)
-
Genomic Structure of the Immigrant Siddis of East Africa to Southern India: A Study of 20 Autosomal DNA Markers
Biochemical Genetics (2011)
-
A Genomic Insight into Diversity Among Tribal and Nontribal Population Groups of Manipur, India
Biochemical Genetics (2009)
-
Genetic variation in South Indian castes: evidence from Y-chromosome, mitochondrial, and autosomal polymorphisms
BMC Genetics (2008)