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Human mesenchymal stem cells: from basic biology to clinical applications

Gene Therapy volume 15, pages 109–116 (2008)Cite this article

Abstract

Mesenchymal stem cells (MSC) are a group of clonogenic cells present among the bone marrow stroma and capable of multilineage differentiation into mesoderm-type cells such as osteoblasts, adipocytes and chondrocytes. Due to their ease of isolation and their differentiation potential, MSC are being introduced into clinical medicine in variety of applications and through different ways of administration. Here, we discuss approaches for isolation, characterization and directing differentiation of human mesenchymal stem cells (hMSC). An update of the current clinical use of the cells is also provided.

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Acknowledgements

The study was supported by grants from the Danish Medical Research Council, the Novo Nordisk Foundation, the Vellux Foundation and Danish Center for Stem Cell Research.

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  1. Department of Endocrinology, Molecular Endocrinology Laboratory (KMEB), Odense University Hospital and Medical Biotechnology Centre, University of Southern Denmark, Odense, Denmark

    B M Abdallah & M Kassem

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Abdallah, B., Kassem, M. Human mesenchymal stem cells: from basic biology to clinical applications. Gene Ther 15, 109–116 (2008). https://doi.org/10.1038/sj.gt.3303067

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