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Effect of weight loss using formula diet on renal function in obese patients with diabetic nephropathy

International Journal of Obesity volume 29, pages 1115–1120 (2005)Cite this article

Abstract

OBJECTIVE:

To evaluate the effect and safety of treatment with low-calorie formula diet on renal function and proteinuria in obese patients with diabetic nephropathy.

DESIGN:

Prospective study on safety and efficacy of a 4-week low-calorie (11–19 kcal/kg/day) normal-protein (0.9–1.2 g/kg/day) diet partly supplemented with formula diet.

SUBJECTS:

In all, 22 obese patients with diabetic nephropathy (BMI: 30.4±5.3 kg/m2, HbA1c: 7.1±1.4%, serum creatinine: 172.4±57.5 μmol/l, urinary protein: 3.3±2.6 g/day).

RESULTS:

The mean body weight decreased by 6.2±3.0 kg. The mean systolic blood pressure, creatinine, blood urea nitrogen, urinary protein, and 8-hydroxydeoxyguanosine decreased significantly by 7.5±12.7 mmHg, 41.6±23.9 μmol/l, 1.50±1.61 mmol/l, 1.8±1.7 g/day, and 3.1±3.6 ng/mg creatinine, respectively. No patient had increased serum creatinine and urinary protein. Mean creatinine clearance (40.6±17.9 to 46.1±14.6 ml/s/1.73 m2) and serum albumin showed no significant changes. Δserum creatinine and Δurinary protein correlated with Δbody weight (r=0.62 and 0.49, respectively) and Δvisceral fat area (r=0.58 and 0.58, respectively), but did not correlate with Δsystolic blood pressure, Δfasting blood glucose and Δsubcutaneous fat area.

CONCLUSION:

These results suggested that weight reduction using formula diet might improve renal function and proteinuria safely for a short term in obese patients with diabetic nephropathy.

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Authors and Affiliations

  1. Center of Diabetes, Endocrine and Metabolism, Sakura Hospital, School of Medicine, Toho University, Chiba, Japan

    A Saiki, M Ohhira, K Endoh, M Ohtsuka, N Koide, T Oyama & Y Miyashita

  2. Internal Medicine, Sakura Hospital, School of Medicine, Toho University, Chiba, Japan

    D Nagayama & K Shirai

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  1. A Saiki
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  2. D Nagayama
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  3. M Ohhira
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Correspondence to Y Miyashita.

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Saiki, A., Nagayama, D., Ohhira, M. et al. Effect of weight loss using formula diet on renal function in obese patients with diabetic nephropathy. Int J Obes 29, 1115–1120 (2005). https://doi.org/10.1038/sj.ijo.0803009

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