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Prevalence and determinants of undertreatment of hypertension in the Netherlands

Abstract

The objective of this study was to determine the prevalence, treatment, and control of hypertension, and the determinants of undertreatment in the Dutch population. The study design was cross-sectional. A population-based survey on cardiovascular disease risk factors in the Netherlands from 1996 to 2002 was the setting of the study. A total of 10 820 men and women, aged 30–59 years, were included in the study. The main outcome measures of the study were: Prevalence of hypertension, treatment, and control of hypertension and determinants of undertreatment of hypertension. Hypertension was defined as: systolic blood pressure (SBP) 140 mmHg and/or diastolic blood pressure (DBP) 90 mmHg, and/or the use of antihypertensive medication. Treated and controlled hypertension was defined as SBP <140 mmHg and DBP <90 mmHg. Multivariate logistic regression was used to assess the determinants of undertreatment. The prevalence of hypertension in men was 21.4% and in women 14.9%, and 17.9% of the hypertensive men and 38.5% of the hypertensive women were receiving antihypertensive medication. Of the untreated hypertensives, 21.9% of the men and 13.6% of the women were eligible for treatment with antihypertensive medication according to Dutch guidelines. Female gender and the use of cholesterol-lowering medication were associated with an increased chance of being treated. Subjects who were physically active, on a low salt diet, and current smokers had an increased chance of being untreated. Taking cholesterol-lowering medication and no asthma or allergy were factors associated with better control of blood pressure. In conclusion, a considerable proportion of hypertensives were untreated and uncontrolled. Therefore, the detection and control of hypertension in the Netherlands needs to improve. Several groups of hypertensives were identified that need additional care and attention.

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References

  1. Brown MJ, Haydock S . Pathoaetiology, epidemiology and diagnosis of hypertension. Drugs 2000; 59 (Suppl 2): 1–12.

    Article  Google Scholar 

  2. Svardsudd K, Tibblin G . Mortality and morbidity during 13.5 years’ follow-up in relation to blood pressure. The study of men born in 1913. Acta Med Scand 1979; 205: 483–492.

    Article  CAS  Google Scholar 

  3. Fiebach NH et al. A prospective study of high blood pressure and cardiovascular disease in women. Am J Epidemiol 1989; 130: 646–654.

    Article  CAS  Google Scholar 

  4. MacMahon S et al. Blood pressure, stroke, and coronary heart disease. Part 1, Prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias. Lancet 1990; 335: 765–774.

    Article  CAS  Google Scholar 

  5. van der Giezen AM et al. Systolic blood pressure and cardiovascular mortality among 13 740 Dutch women. Prev Med 1990; 19: 456–465.

    Article  CAS  Google Scholar 

  6. Kannel WB . Cardioprotection and antihypertensive therapy: the key importance of addressing the associated coronary risk factors (the Framingham experience). Am J Cardiol 1996; 77: 6B–11B.

    Article  CAS  Google Scholar 

  7. Collins R, MacMahon S . Blood pressure, antihyper-tensive drug treatment and the risks of stroke and of coronary heart disease. Br Med Bull 1994; 50: 272–298.

    Article  CAS  Google Scholar 

  8. Gueyffier F, Froment A, Gouton M . New meta-analysis of treatment trials of hypertension: improving the estimate of therapeutic benefit. J Hum Hypertens 1996; 10: 1–8.

    CAS  PubMed  Google Scholar 

  9. Neal B, MacMahon S, Chapman N . Effects of ACE inhibitors, calcium antagonists, and other blood-pressure-lowering drugs: results of prospectively designed overviews of randomised trials. Blood Pressure Lowering Treatment Trialists’ Collaboration. Lancet 2000; 356: 1955–1964.

    Article  CAS  Google Scholar 

  10. Klungel OH et al. Undertreatment of hypertension in a population-based study in The Netherlands. J Hypertens 1998; 16: 1371–1378.

    Article  CAS  Google Scholar 

  11. World Health Organization-International Society of Hypertension Guidelines for the Management of Hypertension. Guidelines Subcommittee. J Hypertens 1999; 17: 151–183.

  12. Verschuren WMM et al. Cardiovascular disease risk factors in The Netherlands. Neth J Cardiol 1993; 4: 205–210.

    Google Scholar 

  13. Jacobsen BK, Thelle DS . Risk factors for coronary heart disease and level of education. The Tromso Heart Study. Am J Epidemiol 1988; 127: 923–932.

    Article  CAS  Google Scholar 

  14. Kraus JF, Borhani NO, Franti CE . Socioeconomic status, ethnicity, and risk of coronary heart disease. Am J Epidemiol 1980; 111: 407–414.

    Article  CAS  Google Scholar 

  15. CBO-consensus. Hoge bloeddruk. Herziening richtlijnen 2000 (in Dutch).

  16. Klungel OH et al. Estimating the prevalence of hypertension corrected for the effect of within-person variability in blood pressure. J Clin Epidemiol 2000; 53: 1158–1163.

    Article  CAS  Google Scholar 

  17. Primatesta P, Brookes M, Poulter NR . Improved hypertension management and control: results from the health survey for England 1998. Hypertension 2001; 38: 827–832.

    Article  CAS  Google Scholar 

  18. de Gaudemaris R et al. Socioeconomic inequalities in hypertension prevalence and care: the IHPAF Study. Hypertension 2002; 39: 1119–1125.

    Article  CAS  Google Scholar 

  19. Gasse C et al. Assessing hypertension management in the community: trends of prevalence, detection, treatment, and control of hypertension in the MONICA Project, Augsburg 1984–1995. J Hum Hypertens 2001; 15: 27–36.

    Article  CAS  Google Scholar 

  20. Wolf-Maier K et al. Hypertension prevalence and blood pressure levels in 6 European countries, Canada, and the United States. Jama 2003; 289: 2363–2369.

    Article  Google Scholar 

  21. De Henauw S et al. Trends in the prevalence, detection, treatment and control of arterial hypertension in the Belgian adult population. J Hypertens 1998; 16: 277–284.

    Article  CAS  Google Scholar 

  22. Di Bari M et al. Undertreatment of hypertension in community-dwelling older adults: a drug-utilization study in Dicomano, Italy. J Hypertens 1999; 17: 1633–1640.

    Article  CAS  Google Scholar 

  23. Shah S, Cook DG . Inequalities in the treatment and control of hypertension: age, social isolation and lifestyle are more important than economic circumstances. J Hypertens 2001; 19: 1333–1340.

    Article  CAS  Google Scholar 

  24. NHG-Standaard Hypertensie. Huisarts Wet 1997; 40: 598–617 (in Dutch).

  25. Chobanian AV et al. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: The JNC 7 Report. Jama 2003; 289: 2560–2571.

    Article  CAS  Google Scholar 

  26. Luscher TF et al. Compliance in hypertension: facts and concepts. J Hypertens Suppl 1985; 3: S3–S9.

    CAS  PubMed  Google Scholar 

  27. Balazovjech I, Hnilica Jr P . Compliance with antihypertensive treatment in consultation rooms for hypertensive patients. J Hum Hypertens 1993; 7: 581–583.

    CAS  PubMed  Google Scholar 

  28. Haynes RB et al. Improvement of medication compliance in uncontrolled hypertension. Lancet 1976; 1: 1265–1268.

    Article  CAS  Google Scholar 

  29. Peterson GM, McLean S, Millingen KS . Determinants of patient compliance with anticonvulsant therapy. Epilepsia 1982; 23: 607–613.

    Article  CAS  Google Scholar 

  30. Morisky DE et al. Evaluation of family health education to build social support for long-term control of high blood pressure. Health Educ Q 1985; 12: 35–50.

    Article  CAS  Google Scholar 

  31. Eisen SA et al. The effect of medication compliance on the control of hypertension. J Gen Intern Med 1987; 2: 298–305.

    Article  CAS  Google Scholar 

  32. Stockwell DH et al. The determinants of hypertension awareness, treatment, and control in an insured population. Am J Public Health 1994; 84: 1768–1774.

    Article  CAS  Google Scholar 

  33. Wilber JA, Barrow JG . Hypertension—a community problem. Am J Med 1972; 52: 653–663.

    Article  CAS  Google Scholar 

  34. Klein LE . Compliance and blood pressure control. Hypertension 1988; 11 (3 Part 2): II61–II64.

    CAS  PubMed  Google Scholar 

  35. Trilling JS, Froom J . The urgent need to improve hypertension care. Arch Fam Med 2000; 9: 794–801.

    Article  CAS  Google Scholar 

  36. Miller NH, Hill M, Kottke T, Ockene IS . The multilevel compliance challenge: recommendations for a call to action. A statement for healthcare professionals. Circulation 1997; 95: 1085–1090.

    Article  CAS  Google Scholar 

  37. Klungel OH et al. Cardiovascular diseases and risk factors in a population-based study in The Netherlands: agreement between questionnaire information and medical records. Neth J Med 1999; 55: 177–183.

    Article  CAS  Google Scholar 

  38. Klungel OH et al. Agreement between self-reported antihypertensive drug use and pharmacy records in a population-based study in The Netherlands. Pharm World Sci 1999; 21: 217–220.

    Article  CAS  Google Scholar 

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Acknowledgements

The management team for the MORGEN-project consisted of Dr HB Bueno de Mesquita, Dr HA Smit, Dr WMM Verschuren, and Professor Dr JC Seidell. Logistic support was provided by A Jansen and J Steenbrink MSc, and data management was performed by A Blokstra MSc, AWD van Kessel MSc, and PE Steinberger MSc. Project leader for the Doetinchem Cohort Study is Dr WMM Verschuren, with logistic support by J Steenbrink MSc and P Vissink, secretarial assistance by EP van der Wolf, and data management by A Blokstra MSc, AWD van Kessel MSc, and PE Steinberger MSc. We thank the epidemiologists and field workers of the Municipal Health Services in Amsterdam, Doetinchem, and Maastricht for their contribution to the data collection for this study. This study is supported by the Netherlands Heart Foundation, Grant number: 2001.064. This study was financially supported by the Ministry of Health, Welfare and Sport of the Netherlands and the National Institute for Public Health and the Environment. Potential conflicts of interest: none.

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Schelleman, H., Klungel, O., Kromhout, D. et al. Prevalence and determinants of undertreatment of hypertension in the Netherlands. J Hum Hypertens 18, 317–324 (2004). https://doi.org/10.1038/sj.jhh.1001672

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