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  • Perinatal/Neonatal Case Presentation
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Perinatal/Neonatal Case Presentation

Tin-mesoporphyrin in the Treatment of Severe Hyperbilirubinemia in a Very-low-birth-weight Infant

Journal of Perinatology volume 23, pages 507–508 (2003)Cite this article

Abstract

Tin-mesoporphyrin (SnMP) is a competitive inhibitor of microsomal heme oxygenase (the rate-limiting enzyme in the heme catabolic pathway). It was administered as a single intramuscular dose at 46 hours of life to a very-low-birth-weight infant with severe hemolytic hyperbilirubinemia who had been awaiting an exchange transfusion. This case documents the effective elimination of the need for an exchange transfusion in a very-low-birth-weight infant and is a confirmation of the experience of others for the use of SnMP in reducing bilirubin production.

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References

  1. Valaes T, Petmezaki S, Henschke C, Drummond GS, Kappas A . Control of jaundice in preterm newborns by an inhibitor of bilirubin production: studies with tin-mesoporphyrin. Pediatrics 1994;93:1–11.

    CAS  PubMed  Google Scholar 

  2. Kappas A, Drummond GS, Henschke C, Valaes T . Direct comparison of Sn-mesoporphyrin an inhibitor of bilirubin production and phototherapy in controlling hyperbilirubinemia in term and near-term newborns. Pediatrics 1995;95:468–474.

    CAS  PubMed  Google Scholar 

  3. Kappas A, Drummond GS, Munson DP, Marshall JR . Sn-mesoporphyrin interdiction of severe hyperbilirubinemia in Jehovah's Witness newborns as an alternative to exchange transfusion. Pediatrics 2001;108:1374–1377.

    Article  CAS  Google Scholar 

  4. Kappas A, Drummond GS, Valaes T . A single dose of Sn-mesoporphyrin prevents development of severe hyperbilirubinemia in glucose-6-phosphate dehydrogenase-deficient newborns. Pediatrics 2001;108:25–30.

    Article  CAS  Google Scholar 

  5. Galbraith RA, Drummond GS, Kappas A . Suppression of bilirubin production in the Crigler–Najjar type I syndrome: studies with the heme oxygenase inhibitor tin-mesoporphyrin. Pediatrics 1992;89:175–182.

    CAS  PubMed  Google Scholar 

  6. Rubaltalli FF, Dario C, Zancan L . Congenital nonobstructive, nonhemolytic jaundice: effect of tin-mesoporphyrin. Pediatrics 1994;95:942–944.

    Google Scholar 

  7. Kappas A, Drummond GS, Manola T, Petmezaki S, Valaes T . Sn-protoporphyrin use in the management of hyperbilirubinemia in term newborns with direct Coombs-positive ABO incompatibility. Pediatrics 1988;81:485–497.

    CAS  Google Scholar 

  8. Maisels MJ . Neonatal jaundice. In: Avery GB, Fletcher MA, MacDonald M, editors. Neonatology: Pathophysiology and Management of the Newborn. Philadelphia, PA: JB Lippincott; 1994.

    Google Scholar 

  9. Martinez JC, Garcia HO, Otheguy LE, Drummond GS, Kappas A . Control of severe hyperbilirubinemia in full-term newborns with the inhibitor of bilirubin production Sn-mesoporphyrin. Pediatrics. 1999;108:25–30.

    Google Scholar 

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Authors and Affiliations

  1. Division of Neonatology, Department of Pediatrics, UMDNJ-Robert Wood Johnson Medical School, Saint Peter's University Hospital, New Brunswick, NJ, USA

    Pradeep Reddy MD, Shakuntala Najundaswamy MD, Rajeev Mehta MD, Anna Petrova MD, PhD, MPH & Thomas Hegyi MD

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  1. Pradeep Reddy MD
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  2. Shakuntala Najundaswamy MD
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  3. Rajeev Mehta MD
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  4. Anna Petrova MD, PhD, MPH
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  5. Thomas Hegyi MD
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Reddy, P., Najundaswamy, S., Mehta, R. et al. Tin-mesoporphyrin in the Treatment of Severe Hyperbilirubinemia in a Very-low-birth-weight Infant. J Perinatol 23, 507–508 (2003). https://doi.org/10.1038/sj.jp.7210943

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