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  • Perinatal/Neonatal Case Presentation
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Perinatal/Neonatal Case Presentation

Amiodarone-Induced Neonatal Hypothyroidism: A Unique Form of Transient Early-Onset Hypothyroidism

Abstract

Amiodarone is an iodine-rich drug used to treat cardiac dysrhythmias. The structure of amiodarone resembles that of thyroxine, and treatment with amiodarone may alter thyroid function. The effects of antenatal amiodarone use on fetal/neonatal thyroid function have only been addressed in a limited number of patient reports. We describe two cases of transient neonatal hypothyroidism due to in utero amiodarone exposure, followed by a brief review of the available literature.

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References

  1. Roy D, Talajic M, Dorian P, Connolly S, Eisenberg MJ, Green M, et al. Amiodarone to prevent recurrence of atrial fibrillation. N Engl J Med 2000;342:913–920.

    Article  CAS  Google Scholar 

  2. Bogazzi F, Bartalena L, Gasperi M, Braverman LE, Martino E . The various effects of amiodarone on thyroid function. Thyroid 2001;11(5):511–519.

    Article  CAS  Google Scholar 

  3. Bartalena L, Bogazzi F, Braverman LE, Martino E . Effects of amiodarone administration during pregnancy on neonatal thyroid function and subsequent neurodevelopment. J Endocrinol Invest 2001;24:116–130.

    Article  CAS  Google Scholar 

  4. Belhassen A, Vaksmann G, Francart C, et al. Value of amiodarone in the treatment of fetal supraventricular tachycardia. Apropos of a case]. J Gynecol Obstet Biol Reprod 1987;16:795–800.

    CAS  Google Scholar 

  5. Bretremieux P, Laurent M, Almange C, et al. Hypothyroidism following maternal treatment with amiodarone]. J Gynecol Obstet Biol Reprod 1988;17:398.

    CAS  Google Scholar 

  6. Aguilar Diosdada M, Jaen Amate F, Gavilan Villarejo I, et al. Neonatal hypothyroidism after amiodarone therapy during pregnancy]. An Med Interna 1992;9:358.

    Google Scholar 

  7. Haffajee CI . In discussion: amiodarone pharmacokinetics. Am Heart J 1983;106:847.

    Article  Google Scholar 

  8. Arnoux P, Seyral P, Llurens M, et al. Amiodarone and digoxin for refractory fetal tachycardia. Am J Cardiol 1987;59:166–167.

    Article  CAS  Google Scholar 

  9. Vanbesien J, Casteels A, Bougatef A, et al. Transient fetal hypothyroidism due to direct fetal administration of amiodarone for drug resistant fetal tachycardia. Am J Perinatol 2001;18:113–116.

    Article  CAS  Google Scholar 

  10. Laurent M, Betremieux P, Biron Y, et al. Neonatal hypothyroidism after treatment by amiodarone during pregnancy. Am J Cardiol 1987;60:942.

    Article  CAS  Google Scholar 

  11. DeWolf D, DeSchepper J, Verhaaren H, et al. Congenital hypothyroid goiter and amiodarone. Acta Paediatr Scand 1988;77:616–618.

    Article  CAS  Google Scholar 

  12. Plomp T, Vulsma T, de Vijlder J . Use of amiodarone during pregnancy. Eur J Obstet Gynecol Reprod Biol 1992;43:201–207.

    Article  CAS  Google Scholar 

  13. Matsumura L, Born D, Kunii I, et al. Outcome of thyroid function in newborns from mothers treated with amiodarone. Thyroid 1992;2:279–281.

    Article  CAS  Google Scholar 

  14. Darwiche A, Vanlieferinghen P, Lemery D, et al. Amiodarone and fetal SVT. Apropos of a case with neonatal hypothyroidism]. Arch Fr Pediatr 1992;49:729–731.

    CAS  PubMed  Google Scholar 

  15. Ovadia M, Brito M, Hoyer G, et al. Human experience with amiodarone in the embryonic period. Am J Cardiol 1994;73:316–317.

    Article  CAS  Google Scholar 

  16. DeCatte L, DeWolf D, Smitz J, et al. Fetal hypothyroidism as a complication of amiodarone treatment of persistent fetal SVT. Prenat Diagn 1994;14:762–765.

    Article  CAS  Google Scholar 

  17. Grosso S, Berardi R, Cioni M, et al. Transient neonatal hypothyroidism after gestational exposure to amiodarone: a follow-up of two cases. J Endocrinol Invest 1998;21:699–702.

    Article  CAS  Google Scholar 

  18. Magee L, Downar E, Sermer M, et al. Pregnancy outcome after gestational exposure to amiodarone in Canada. Am J Obstet Gynecol 1995;172:1307–1311.

    Article  CAS  Google Scholar 

  19. Widerhorn J, Bhandari A, Bughi S, et al. Fetal and neonatal adverse effects profile of amiodarone treatment during pregnancy. Am Heart J 1991;122:1162–1166.

    Article  CAS  Google Scholar 

  20. Magee L, Nulman I, Rovet J, et al. Neurodevelopment after in utero amiodarone exposure. Neurotoxicol Teratol 1999;21:261–265.

    Article  CAS  Google Scholar 

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Lomenick, J., Jackson, W. & Backeljauw, P. Amiodarone-Induced Neonatal Hypothyroidism: A Unique Form of Transient Early-Onset Hypothyroidism. J Perinatol 24, 397–399 (2004). https://doi.org/10.1038/sj.jp.7211104

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