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Spotlight on Molecular Targeted Therapy

Nuclear transcription factor-κB as a target for cancer drug development

Leukemia volume 16, pages 1053–1068 (2002)Cite this article

Abstract

Nuclear factor kappa B (NF-κB) is a family of inducible transcription factors found virtually ubiquitously in all cells. Since its discovery by Sen and Baltimore in 1986, much has been discovered about its mechanisms of activation, its target genes, and its function in a variety of human diseases including those related to inflammation, asthma, atherosclerosis, AIDS, septic shock, arthritis, and cancer. Due to its role in a wide variety of diseases, NF-κB has become one of the major targets for drug development. Here, we review our current knowledge of NF-κB, the possible mechanisms of its activation, its potential role in cancer, and various strategies being employed to target the NF-κB signaling pathway for cancer drug development.

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Acknowledgements

This research was supported by grants from The Clayton Foundation for Research, from National Institute of Health (P01 CA91844), and from Department of Defence to one of us (BBA). We would like to thank Walter Pagel for his critical comments.

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  1. Department of Bioimmunotherapy, Cytokine Research Laboratory, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    A Garg & BB Aggarwal

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Garg, A., Aggarwal, B. Nuclear transcription factor-κB as a target for cancer drug development. Leukemia 16, 1053–1068 (2002). https://doi.org/10.1038/sj.leu.2402482

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