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CIZ gene rearrangements in acute leukemia: report of a diagnostic FISH assay and clinical features of nine patients

Leukemia volume 19, pages 1696–1699 (2005)Cite this article

TO THE EDITOR

After designing the first FISH assay to reveal CIZ (also known as ZNF384) rearrangements, we report details of clinical and hematological features associated with CIZ translocation.

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References

  1. Martini A, La Starza R, Janssen H, Bilhou-Nabera C, Corveleyn A, Somers R et al. Recurrent rearrangement of the Ewing's sarcoma gene, EWSR1, or its homologue, TAF15, with the transcription factor CIZ/NMP4 in acute leukemia. Cancer Res 2002; 62: 5408–5412.

    CAS  PubMed  Google Scholar 

  2. Zucman J, Delattre O, Desmaze C, Plougastel B, Joubert I, Melot T et al. Cloning and characterization of the Ewing's sarcoma and peripheral neuroepithelioma t(11;22) translocation breakpoint. Genes Chromosomes Cancer 1992; 5: 271–277.

    Article  CAS  Google Scholar 

  3. Krance RA, Raimondi SC, Dubowy R, Estrada J, Borowitz M, Behm F et al. T(12;17)(p13;q21) in early pre-B acute lymphoid leukemia. Leukemia 1992; 6: 251–255.

    CAS  PubMed  Google Scholar 

  4. Cimino G, Elia L, Mancini M, Annino L, Anaclerico B, Fazi P, et al., for the GIMEMA Group. Clinico-biologic features and treatment outcome of adult pro-B-ALL patients enrolled in the GIMEMA 0496 study: absence of the ALL1/AF4 and of the BCR/ABL fusion genes correlates with a significantly better clinical outcome. Blood 2003; 102: 2014–2020.

    Article  CAS  Google Scholar 

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Acknowledgements

This work was supported by AIRC (Associazione Italiana Ricerca sul Cancro), CNR-MIUR (Consiglio Nazionale delle Ricerche, Ministero per l’Istruzione, l’Università e la Ricerca Scientifica), EU (European Comunity), Fondazione Cassa di Risparmio di Perugia, Associazione ‘Sergio Luciani’ Fabriano, Italy, and Belgian Programme of Interuniversity Poles of Attraction initiated by Belgian State, Prime Minister's Office, Science Policy Programming. Cosmids G9 and F7 were provided by G Thomas, Institut Curie, Paris; cosmids 106.2 and 106.3 by F Birg, University of Marseille, France; BAC for Ikaros by Y Hosokawa, Aichi Cancer Center Research Institute, Japan; PAC1107L6 by M Rocchi, DAPEG, University of Bari, Italy; and PAC 546C11 by J Flint, Oxford, UK. We thank Professor E Miraglia and Dr D De Blasi for patient 4's clinical data and Dr Geraldine Boyd for assistance in the preparation of the manuscript.

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Authors and Affiliations

  1. Hematology and Bone Marrow Transplantation Unit, University of Perugia, Policlinico Monteluce, Perugia, Italy

    R La Starza, B Crescenzi, P Gorello, M F Martelli & C Mecucci

  2. Departament d'Hematologia, Hospital de Sant Pau, Barcelona, Spain

    A Aventin

  3. Hematology, University of Foggia, Foggia, Italy

    G Specchia

  4. Hematology, University of Ferrara, Ferrara, Italy

    A Cuneo

  5. Hospital ‘Bambino Gesù’, Genetic Service, Roma, Italy

    A Angioni

  6. Service du Pr Praloran, Hospital du Haut-Leveque, CHU, Bordeaux, Pessac, France

    C Bilhou-Nabera

  7. Servei d'Hematologia, Institut Català d'Oncologia, Barcelona, Spain

    C Boqué

  8. Hematology, University ‘La Sapienza’, Policlinico Umberto I, Roma, Italy

    R Foà & G Cimino

  9. Paediatric Hematology, Campus Gasthuisberg, Leuven, B-3000, Belgium

    A Uyttebroeck

  10. Laboratoire de Cytogénétique Hématologique, Hotel Dieu, Nantes, France

    P Talmant

  11. Center for Human Genetics and Flanders Interuniversity Institute for Biotechnology (VIB), University of Leuven, Campus Gasthuisberg, Leuven, B-3000, Belgium

    P Marynen & A Hagemeijer

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  1. R La Starza
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  2. A Aventin
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  8. C Bilhou-Nabera
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  9. C Boqué
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  12. P Talmant
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  13. G Cimino
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  14. M F Martelli
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  15. P Marynen
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  16. C Mecucci
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  17. A Hagemeijer
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Corresponding author

Correspondence to C Mecucci.

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La Starza, R., Aventin, A., Crescenzi, B. et al. CIZ gene rearrangements in acute leukemia: report of a diagnostic FISH assay and clinical features of nine patients. Leukemia 19, 1696–1699 (2005). https://doi.org/10.1038/sj.leu.2403842

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  • DOI: https://doi.org/10.1038/sj.leu.2403842

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