Abstract
A number of consistent clinical observations provide direction for the hypothesis that pathological sensitization of neuronal systems may be an important factor for relapse or the onset of stimulant-induced psychosis (eg, methamphetamine or amphetamine psychosis, cocaine psychosis and phencyclidine psychosis) and schizophrenia. First, psychotic symptoms can be produced in normal subjects by stimulants. Secondly, a large portion of schizophrenic patients exhibit exacerbation of psychotic symptoms in response to stimulants at doses which would not be psychotogenic in normal subjects. Lastly, the ability of stress to precipitate the onset and relapse of schizophrenia is well documented. In this regard, acute responses to stimulants provide useful information for relapse prediction of schizophrenia and substance abuse. This paper addresses the nature and role of pathological sensitization in relapse of stimulant- and phencyclidine-induced psychosis and schizophrenia, and its relation to pathophysiology of schizophrenia.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Corresponding author
Additional information
An edited symposium of the XXth Collegicum Internationale Neuro Psychopharmacologicum (CINP) Congress held on June 25, 1996 at Melbourne, Australia. This paper included four manuscripts contributed by the four presenters of the XXth CINP Congress.
Rights and permissions
About this article
Cite this article
Yui, K., Goto, K., Ikemoto, S. et al. Neurobiological basis of relapse prediction in stimulant-induced psychosis and schizophrenia: the role of sensitization. Mol Psychiatry 4, 512–523 (1999). https://doi.org/10.1038/sj.mp.4000575
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.mp.4000575
Keywords
This article is cited by
-
Haloperidol rescues the schizophrenia-like phenotype in adulthood after rotenone administration in neonatal rats
Psychopharmacology (2021)
-
Enduring effects of juvenile social isolation on physiological properties of medium spiny neurons in nucleus accumbens
Psychopharmacology (2019)
-
Neuregulin-2 ablation results in dopamine dysregulation and severe behavioral phenotypes relevant to psychiatric disorders
Molecular Psychiatry (2018)
-
Current understanding of methamphetamine-associated dopaminergic neurodegeneration and psychotoxic behaviors
Archives of Pharmacal Research (2017)
-
Psychopathological symptoms of patients with heroin addiction entering opioid agonist or therapeutic community treatment
Annals of General Psychiatry (2014)