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Association analysis of adenylate cyclase type 9 gene using pedigree disequilibrium test in bipolar disorder

Molecular Psychiatry volume 7, pages 450–452 (2002)Cite this article

SIR – Chromosome 16 short arm has been shown to display modest linkage signals for mood disorders in a number of studies.1,2,3 An interesting candidate gene in this region is the adenylate cyclase type 9 gene (ADCY9) on 16p13.3, because adenylate cyclases (ACs) are critical in neuronal signaling, and perturbation of AC activity has been reported in mood disorder postmortem brains,4 with additional supporting evidence that AC may act as targets of antidepressants and mood stabilizers.5 In the present study, we investigated the potential role of ADCY9 in mood disorders, by using a newly developed family-based association analysis.

We first delineated the genomic organization of the ADCY9 gene by aligning the sequence of BAC clone (GenBank Acc. No. AC005736) and the sequences of EST/cDNA clones (T08314, AF036927 and AB011092) in the database, revealing that ADCY9 was composed of 11 exons, spanning a region greater than 150 kb. All exon boundaries followed the GT–AG rule. The initiation and termination codons were in exons 2 and 11, respectively. This information was deposited into GenBank under the Acc. Nos. AY028948 through to AY028957 and AY028959.

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References

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  9. Detera-Wadleigh SD et al. Proc Natl Acad Sci USA 1999 96: 5604–5609

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Authors and Affiliations

  1. Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, 351-0198, Saitama, Japan

    T Toyota, K Yamada, K Saito & T Yoshikawa

  2. Department of Neuropsychiatry, Tokyo Medical and Dental University, Tokyo, Japan

    T Toyota

  3. National Institute of Mental Health, Intramural Research Program, Bethesda, 20892–4094, MD, USA

    S D Detera-Wadleigh

Authors
  1. T Toyota
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  2. K Yamada
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  3. K Saito
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  4. S D Detera-Wadleigh
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  5. T Yoshikawa
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Correspondence to T Yoshikawa.

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Toyota, T., Yamada, K., Saito, K. et al. Association analysis of adenylate cyclase type 9 gene using pedigree disequilibrium test in bipolar disorder. Mol Psychiatry 7, 450–452 (2002). https://doi.org/10.1038/sj.mp.4000992

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